RESUMO
Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C20 quassinoids, including nine new quassinoid glycosides, named chuglycosides A-I (1-6 and 8-10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed potent anti-tobacco mosaic virus (TMV) activity. A preliminary structure-anti-TMV activity relationship of quassinoids was discussed. The effects of three quassinoids, including chaparrinone (12), glaucarubinone (15), and ailanthone (16), on the accumulation of TMV coat protein (CP) were studied by western blot analysis. Ailanthone (16) was further investigated for its influence on TMV spread in the Nicotiana benthamiana plant.
Assuntos
Ailanthus/química , Antivirais/farmacologia , Extratos Vegetais/farmacologia , Quassinas/farmacologia , Vírus do Mosaico do Tabaco/efeitos dos fármacos , Antivirais/química , Antivirais/isolamento & purificação , Doenças das Plantas/virologia , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Quassinas/química , Quassinas/isolamento & purificação , Relação Estrutura-Atividade , Nicotiana/virologia , Vírus do Mosaico do Tabaco/fisiologiaRESUMO
A new Erythrina alkaloid glycoside, named erythraline-11ß-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid. The structure of the new alkaloid glycoside was elucidated by spectroscopic methods, and all of the compounds were evaluated for their antiviral activity against tobacco mosaic virus.