RESUMO
New nitrogen-containing derivatives of betulinic and betulonic acids, hydrazides and N'-benzalhydrazides, were synthesized. Their antiviral activities toward of influenza A virus, herpes simplex type I virus, enterovirus ECHO6, and HIV-1 were studied in vitro. Betulinic acid 3-oxime was found to have the highest activity against the influenza virus. Betulonic acid, betulinic acid 4-chlorobenzalhydrazide, betulonic acid 3-oxime benzalhydrazide, and betulinic acid hydrazide inhibited the replication of herpes simplex type I virus. Betulinic acid hydrazide also showed antiviral activity toward HIV-1. All the derivatives of betulinic acid under study displayed a low antiviral activity toward enterovirus ECHO6.
Assuntos
Antivirais/química , Antivirais/farmacologia , Hidrazinas/química , Triterpenos/química , Animais , Antivirais/síntese química , Bioquímica/métodos , Células Cultivadas/virologia , Embrião de Galinha , Avaliação Pré-Clínica de Medicamentos/métodos , Enterovirus/efeitos dos fármacos , HIV-1/efeitos dos fármacos , Herpesvirus Humano 1/efeitos dos fármacos , Humanos , Hidrazinas/síntese química , Hidrazinas/farmacologia , Vírus da Influenza A/efeitos dos fármacos , Oximas/síntese química , Oximas/química , Oximas/farmacologia , Triterpenos Pentacíclicos , Relação Estrutura-Atividade , Triterpenos/farmacologia , Ácido BetulínicoRESUMO
Antiviral properties of betulin, betulinic and betulonic acids were investigated in cell cultures infected with herpes simplex type I, influenza FPV/Rostock and ECHO 6 viruses. All studied triterpenes were active against herpes simplex virus. Betulin and especially betulinic acid also suppressed ECHO 6 virus reproduction.