1.
Bioorg Med Chem Lett
; 14(12): 3069-72, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15149646
RESUMO
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.