RESUMO
The antioxidant and larvicidal activities of Tephrosia egregia extracts and its major component, dehydrorotenone, were studied. High antioxidant activity was found for dehydrorotenone and methanol and ethyl acetate extracts from roots and stems, respectively. Among the tested extracts, the hexane extract from stems showed potent larvicidal activity (LC50 12.88 +/- 0.64) while low activity was found for dehydrorotenone.
Assuntos
Aedes , Inseticidas/química , Tephrosia/química , Animais , Antioxidantes/química , Antioxidantes/isolamento & purificação , Antioxidantes/farmacologia , Inseticidas/isolamento & purificação , Dose Letal Mediana , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Caules de Planta/químicaRESUMO
The present review focus in quinones found in species of Brazilian northeastern Capraria biflora, Lippia sidoides, Lippia microphylla and Tabebuia serratifolia. The review cover ethnopharmacological aspects including photography of species, chemical structure feature, NMR datea and biological properties. Chemical transformations of lapachol to form enamine derivatives and biological activities are discussed.
Assuntos
Lippia/química , Quinonas/química , Quinonas/farmacologia , Scrophulariaceae/química , Tabebuia/química , Brasil , Espectroscopia de Ressonância MagnéticaRESUMO
The ethanolic extract of the fruit bark from Magonia glabrata yielded shikimic acid, scopoletin, sitosterol glycoside and 2-O-methyl-l-inositol. Antioxidant, icthyotoxicity and brine shrimp lethality activities were observed in this extract. The major constituent, 2-O-methyl-l-inositol, was found to be inactive in two assays but showed moderate activity as a radical scavenger.
Assuntos
Antioxidantes/farmacologia , Fitoterapia , Extratos Vegetais/farmacologia , Sapindaceae , Animais , Antioxidantes/administração & dosagem , Antioxidantes/uso terapêutico , Artemia/efeitos dos fármacos , Compostos de Bifenilo , Peixes , Frutas , Picratos/química , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Extratos Vegetais/toxicidadeRESUMO
Capraria biflora L. (Scrophulariaceae) is a perennial shrub widely distributed in several countries of tropical America. The present work verified the cytotoxic and antioxidant potential of biflorin, an o-naphthoquinone isolated from C. biflora collected in the northeast region of Brazil. The cytotoxicity was tested on three different animal cell models: mouse erythrocytes, sea urchin embryos and tumor cells, while the antioxidant activity was assayed by the thiocyanate method. Biflorin lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all five tested tumor cell lines, especially the skin, breast and colon cancer cells with IC50 of 0.40, 0.43 and 0.88 micro/ml for B16, MCF-7 and HCT-8, respectively. Biflorin also showed potent antioxidant activity against autoxidation of oleic acid in a water/alcohol system.
Assuntos
Antineoplásicos/química , Antioxidantes/isolamento & purificação , Sobrevivência Celular/efeitos dos fármacos , Naftoquinonas/química , Naftoquinonas/farmacologia , Fitoterapia , Scrophulariaceae/química , Animais , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Antioxidantes/farmacologia , Neoplasias da Mama , Linhagem Celular Tumoral , Neoplasias do Colo , Feminino , Células HL-60 , Humanos , Leucemia , Melanoma Experimental , Camundongos , Mitose/efeitos dos fármacos , Naftoquinonas/isolamento & purificação , Óvulo/citologia , Óvulo/efeitos dos fármacos , Raízes de Plantas/química , Ouriços-do-MarRESUMO
Isocatalpanol and tecomaquinone I were obtained from roots of Lippia sidoides, a medicinal plant from northeast Brazil. Reduction of tecomaquinone I with NaBH4 yielded a new derivative. Structural elucidation was done on the basis of spectral data, mainly by high-field NMR and electron ionization mass spectrometry.