RESUMO
BACKGROUND: Blood loss is common during surgical procedures, especially in open cardiac surgery. Allogenic blood transfusion is associated with increased morbidity and mortality. Blood conservation programs in cardiac surgery recommend re-transfusion of shed blood directly or after processing, as this decreases transfusion rates of allogenic blood. But aspiration of blood from the wound area is often associated with increased hemolysis, due to flow induced forces, mainly through development of turbulence. METHODS: We evaluated magnetic resonance imaging (MRI) as a qualitative tool for detection of turbulence. MRI is sensitive to flow; this study uses velocity-compensated T1-weighted 3D MRI for turbulence detection in four geometrically different cardiotomy suction heads under comparable flow conditions (0-1250 mL/min). RESULTS: Our standard control suction head Model A showed pronounced signs of turbulence at all flow rates measured, while turbulence was only detectable in our modified Models 1-3 at higher flow rates (Models 1 and 3) or not at all (Model 2). CONCLUSIONS: The comparison of flow performance of surgical suction heads with different geometries via acceleration-sensitized 3D MRI revealed significant differences in turbulence development between our standard control Model A and the modified alternatives (Models 1-3). As flow conditions during measurement have been comparable, the specific geometry of the respective suction heads must have been the main factor responsible. The underlying mechanisms and causative factors can only be speculated about, but as other investigations have shown, hemolytic activity is positively associated with degree of turbulence. The turbulence data measured in this study correlate with data from other investigations about hemolysis induced by surgical suction heads. The experimental MRI technique used showed added value for further elucidating the underlying physical phenomena causing blood damage due to non-physiological flow.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Hemólise , Humanos , Sucção , Imageamento por Ressonância Magnética , Transfusão de Sangue Autóloga/métodosRESUMO
Blood hemolysis caused by mechanical impact is a serious problem in medicine. In addition to the heart-lung machine (artificial surfaces, flow irritating connection points) which contributes to hemolysis, blood suction and surgical suction devices are influencing factors. Goal of our research is to develop best flow optimizing suction geometry that represents the best compromise between all influencing effects. Based on data that negative pressure and turbulence have a negative impact on blood components, 27 surgical suction tips have been examined for acoustic stress and negative pressure behavior. Furthermore, a dimensionless factor Q was introduced to assess the overall performance of the suction tips investigated.
Assuntos
Transfusão de Sangue Autóloga , Ponte Cardiopulmonar , Máquina Coração-Pulmão , Hemólise , Humanos , SucçãoRESUMO
OBJECTIVES: Patients undergoing coronary artery bypass graft (CABG) surgery are exposed to multiple treatment-related stressors, which can impact coping and health-related quality of life (HRQoL). The objective of this trial was to analyse the feasibility and preliminary efficacy of a multi-component intervention that combines psychological support and reduction of hospital-specific stressors on HRQoL, length of hospital and intensive care unit stay, self-efficacy, and plasma interleukin (IL)-6 and -8 levels in CABG patients. METHODS: This three-arm, randomized controlled, single-centre pilot trial assessed the Intervention for CABG to Optimize Patient Experience in 88 patients undergoing elective CABG. Standard medical care (SMC, n = 29) was compared with 2 intervention groups: (i) psychological interventions to optimize treatment expectations (IA group, n = 30) and (ii) multi-component intervention (IB group, n = 29) with psychological interventions plus an additional treatment package (light therapy, noise reduction, music, and if desired, 360° images delivered via virtual reality). RESULTS: The implementation of psychological interventions in routine medical treatment was feasible (91.5% of participants completed all intervention sessions). Both interventions were associated with significantly shorter hospital stay compared to SMC (IA/IB 9.8/9.3 days vs SMC 12.5 days). Self-efficacy expectations at post-surgery were significantly higher compared to SMC both in the IA group (P = 0.011) and marginally in the IB group (P = 0.051). However, there were no treatment effects of the interventions on HRQoL and plasma levels of IL-6 or IL-8 after CABG. CONCLUSIONS: A perioperative multi-component intervention may lead to shorter hospital stay and higher self-efficacy after CABG. Further studies are needed to determine its impact on HRQoL and inflammation. CLINICAL TRIAL REGISTRATION NUMBER: Ethical approval (# 21/2/18) for the study was obtained from the Research Ethics Committee of the University of Göttingen Medical Center, and the trial was registered in the German Clinical Trials Register (DRKS00015309, https://www.drks.de/drks_web/setLocale_EN.do).
Assuntos
Ponte de Artéria Coronária , Qualidade de Vida , Adaptação Psicológica , Ponte de Artéria Coronária/métodos , Estudos de Viabilidade , HumanosRESUMO
BACKGROUND: Re-transfusion of autologous blood is an important aspect of intraoperative blood management. Hemolysis and platelet dysfunction due to turbulence in the blood suction system strongly impede later usage of suction blood for re-transfusion. The aim of this study was to analyze the effects of a novel surgical-blood suction system with an automatic control setup for minimization of turbulence in the blood flow. METHODS: We compared the turbulence-controlled suction system (TCSS) with a conventional suction system and untreated control blood in vitro. Blood cell counts, hemolysis levels according to free hemoglobin (fHb) and platelet function were analyzed to determine the integrity of the suction blood. RESULTS: In the conventional suction system, we found a strong increase of the fHb levels. In contrast, erythrocyte integrity was almost completely preserved when using the TCSS. We obtained similar results regarding platelet function. The expression of platelet glycoproteins, such as GP IIb/IIIa and P-selectin, native or after stimulation with ADP, were markedly impaired by the conventional system, but not by the TCSS. In addition, platelet aggregometry revealed significant platelet dysfunction in conventional suction blood, but less aggregation impairments were present in blood samples from the TCSS. CONCLUSION: Our findings on an in vitro assessment show major improvements in red blood cell integrity and platelet function of suction blood when using the TCSS compared to a conventional suction system. These results reflect a significant benefit for autologous re-transfusion. We suggest testing the TCSS in surgery for clinical evaluation.
Assuntos
Perda Sanguínea Cirúrgica/prevenção & controle , Plaquetas/patologia , Transfusão de Sangue Autóloga , Hemólise , Sucção/instrumentação , Ponte Cardiopulmonar , Hemoglobinas/análise , Hemostasia , Humanos , Testes de Função Plaquetária , Estudos Prospectivos , Procedimentos Cirúrgicos VascularesRESUMO
AIM: This study was aimed at investigating the availability and prescription of different medicinal variants of cannabis and their status in European countries. METHODS: A -web-based survey was sent to all member societies of the -European Federation of Addiction Societies (EUFAS) in 2 waves during the summer of 2017. All 34 member societies in 19 different European countries were invited to participate. RESULTS: We received 28 responses from 17 European countries. The cannabis extract nabiximol (Sativex®) is the most prevalent cannabis-based medicinal product marketed in Europe. Synthetic cannabinoids and standardized cannabis are less prevalent, and no country allows the growing of cannabis for personal medical use. The bringing of medical cannabis products from across borders to countries where the drug is not marketed is quite limited. The use of medical cannabis is restricted to some central medical conditions, but off-label use is prevalent in some countries. CONCLUSION: The use of medical cannabis in Europe seems to be restricted mostly to the use of the cannabis extract, nabiximol. There is only limited use of the cannabis plant as such for medical purposes, possibly indicating a different scenario in Europe as compared to the USA. Position Statement: EUFAS as an umbrella association of European addiction societies stresses the need for further studies on the efficacy of medical cannabis and warrants for possible dangers associated with the increasing popularity of medical cannabis. We need regulations at European level concerning registration and medical indications, development of uniform compounds and strength of products, and rules concerning sales and marketing.
Assuntos
Analgésicos/uso terapêutico , Internet/tendências , Maconha Medicinal/uso terapêutico , Inquéritos e Questionários , Canabidiol/uso terapêutico , Dronabinol/análogos & derivados , Dronabinol/uso terapêutico , Combinação de Medicamentos , Europa (Continente)/epidemiologia , HumanosRESUMO
The role of calcifediol in the perception of chronic pain is a widely discussed subject. Low serum levels of calcifediol are especially common in patients with severe pain and fibromyalgia syndrome (FMS). We lack evidence of the role of vitamin D supplementation in these patients. To our knowledge, no randomized controlled trial has been published on the subject. Thirty women with FMS according to the 1990 and 2010 American College of Rheumatology criteria, with serum calcifediol levels <32ng/mL (80nmol/L), were randomized to treatment group (TG) or control group (CG). The goal was to achieve serum calcifediol levels between 32 and 48ng/mL for 20weeks via oral supplementation with cholecalciferol. The CG received placebo medication. Re-evaluation was performed in both groups after a further 24weeks without cholecalciferol supplementation. The main hypothesis was that high levels of serum calcifediol should result in a reduction of pain (visual analog scale score). Additional variables were evaluated using the Short Form Health Survey 36, the Hospital Anxiety and Depression Scale, the Fibromyalgia Impact Questionnaire, and the Somatization subscale of Symptom Checklist-90-Revised. A marked reduction in pain was noted over the treatment period in TG: a 2 (groups)×4 (time points) variance analysis showed a significant group effect in visual analog scale scores. This also was correlated with scores on the physical role functioning scale of the Short Form Health Survey 36. Optimization of calcifediol levels in FMS had a positive effect on the perception of pain. This economical therapy with a low side effect profile may well be considered in patients with FMS. However, further studies with larger patient numbers are needed to prove the hypothesis.
Assuntos
Fibromialgia/diagnóstico , Fibromialgia/tratamento farmacológico , Medição da Dor/métodos , Vitamina D/uso terapêutico , Adulto , Método Duplo-Cego , Feminino , Fibromialgia/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Vitamina D/sangueRESUMO
Parte inseparável e tenaz da vida animal, as doenças infecciosas acompanharam e moldaram a história do homem na terra, sobretudo quando começou a viver em aglomerados. No Novo Mundo, com a chegada dos europeus, manifestaram-se como a guerra biológica da conquista. Atingindouma população indígena imunologicamente incapaz de combatê-las, a gripe, o sarampo e a varíola selaram o destino de milhões. Neste estudo, objetivamos relatar a catástrofe que representou a varíola para o Brasil, visto que matou de 30por cento a 50por cento de suas vítimas indígenas, desestruturou toda asociedade nativa, causou danos imensos à economia colonial e fomentou o tráfico negreiro.
Assuntos
História do Século XVI , História do Século XVII , Medicina Tradicional/história , Povos Indígenas , Varíola/epidemiologia , Brasil/etnologiaRESUMO
Isolados durante milhares de anos, os indígenas não desenvolveram imunidade diante de vírus e bactérias originários de outros continentes. Apesar de seu habitat não ser destituído de uma grande variedade de moléstias (dentre elas o pian, a leishmaniose cutânea e a doença de Chagas), no contato com o colonizador, a deficiência de resposta imune Th2 para micro-organismos autóctones causou verdadeiras tragédias entre os brasilíndios, que sucumbiam por gripes, sarampo, disenterias e principalmente varíola. Médicos formados constituíam um grupo insignificante no Brasil colonial e diante do vazio profissional, jesuítas (os primeiros que se lançaram nas práticas médicas), curiosos, curandeiros, barbeiros, benzedeiras compunham um contingente expressivo. Todos praticavam uma medicina híbrida, formada inicialmente pela medicina popular européia e indígena; ambas possuíam uma noção materializada da doença que, uma vez instituída, deveria abandonar o organismo. Diante disso, a terapêutica baseava-se em sangrias, purgas e vomitórios, além de rituais, rezas e uso de amuletos para satisfazer o sobrenatural. Estas práticas médicas concomitantemente valeram-se da variada flora medicinal nativa e foram difundidas pelos bandeirantes, que desbravavam os sertões de norte a sul - por este motivo esta terapêutica foi denominada "Remédios de Paulistas" - e foi usada para diversos males como opilação (anemia), escrófulas...
Isolated during thousands of years, native Brazilians did not developed immunity to microorganisms from another continent. Despite the presence of diseases in their habitat, (such as non venereal treponematosis, cutaneous leshmaniosis and Chagas' disease), with exposure to alien explorers, the deficiency of an immune response Th2 to viruses and foreign bacteria, truly decimated the native population of Brazil, which succumbed secondary to primarily small pox, but also to the flu, measles and dysentery. Trained physicians were scarce in colonial Brazil, and due to this professional void, Jesuits (the first to start medical practices), curious people, shamans, barbers and faith healers tried to replace them; all practiced a hybrid form of medicine, based initially in the popular European medicine combined with native roots. Both schools of thought had a "material" concept of the diseases; that is, once developed, it had to abandon the organism. As such, therapy was based in exsanguinations, intestinal cleansing and forced vomit, in addition to rituals, praying and use of amulets to appease the supernatural world. These medical practices made extensive use of the varied medicinal flora, and this knowledge was spread out by the alien explorers of the north and south remote regions - as a consequence, this therapy was called "Remedios de Paulistas", i.e., Medicine of Sao Paulo -, and it was used for a variety of maladies such as anemia, scrofula...