Serum cannabidiol, tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a low-THC Cannabis sativa extract in beagles.

Cannabinoids hold promise for treating health problems related to inflammation and chronic pain in dogs, in particular cannabidiol (CBD), and its native acid derivative cannabidiolic acid (CBDA). Information regarding systemic delivery of cannabinoids through transdermal routes is sparse. The purpose of this study was to determine pharmacokinetics of transdermal administration of a low-THC Cannabis sativa extract in healthy dogs. Six purpose-bred research beagles were treated with a transdermal CBD-CBDA-rich extract, and serum concentrations of CBD, CBDA, tetrahydrocannabinol (THC), and its acid derivative tetrahydrocannabinolic acid (THCA) were examined prior to and at the end of weeks 1 and 2. A 4 mg/kg dose of total cannabinoids twice daily resulted in appx 10 ng/ml of CBD, 21-32 ng/ml of CBDA, trace amounts of THCA, and unquantifiable amounts of THC in serum at the end of weeks 1 and 2 of treatment. Results showed that CBDA and THCA were absorbed better systemically than CBD or THC.

Internet survey of feeding, dietary supplement, and rehabilitative medical management use in flyball dogs.

A survey was designed to investigate the prevalence and characteristics of feeding, dietary supplement use, and rehabilitative management use in flyball dogs. The survey was completed by 394 respondents. There were 12.5% (n = 49/392) and 33.4% (n = 131/392) of owners who fed home-cooked and raw diets, respectively, to their dogs. About 77.7% (n = 306/394) and 56.6% (n = 223/394) of owners used dietary supplement and rehabilitative management, respectively, primarily joint supplements (89.8%, n = 275/306) and chiropractic (73.1%, n = 163/223). Owners were more likely to use supplements (P = 0.0002) and rehabilitative management (P = 0.0001) when their dogs were injured. Dogs with more than one reported injury received rehabilitative management (P < 0.0001) and used supplement (P = 0.0006) more often. Key clinical message: There is considerable demand for non-commercial food, supplements, and rehabilitative management among flyball dog owners, underscoring the importance for veterinarians to understand the motivation of dog owners' decisions as well as the risks and benefits of these practices to ensure optimal outcomes for their patients.

Sondage par internet sur l'alimentation, les suppléments nutritifs et la gestion médicale de réadaptation de chiens pratiquant le flyball. Un sondage a été élaboré afin d'étudier la prévalence et les caractéristiques de l'alimentation, l'utilisation de suppléments nutritifs et la gestion de l'utilisation de la réadaptation chez les chiens pratiquant le flyball, Le sondage fut complété par 394 répondants. Il y avait 12,5 % (n = 49/392) et 33,4 % (n = 131/392) des propriétaires qui nourrissaient leurs chiens avec une alimentation cuite maison et une alimentation crue, respectivement. Environ 77,7 % (n = 306/394) et 56,6 % (n = 223/394) des propriétaires utilisaient des suppléments nutritifs et une gestion de réadaptation, respectivement, principalement des suppléments articulaires (89,8 %, n = 275/306) et de la chiropractie (73,1 %, n = 163/223). Les propriétaires étaient plus enclins à utiliser des suppléments (P = 0,0002) et une gestion de réadaptation (P = 0,0001) lorsque leurs chiens étaient blessés. Les chiens avec plus d'une blessure rapportée ont reçu une gestion de réadaptation (P < 0,0001) et utilisaient des suppléments (P = 0,0006) plus souvent.Message clinique clé:Il y a une demande considérable pour des aliments non-commerciaux, des suppléments et une gestion de la réadaptation chez les propriétaires de chiens pratiquant le flyball, soulignant l'importance pour les vétérinaires de comprendre la motivation des propriétaires de chiens dans leurs décisions aussi bien que les risques et bénéfices de ces pratiques afin d'assurer les meilleurs résultats pour leurs patients.(Traduit par Dr Serge Messier).