RESUMO
Nasal spray products containing desmopressin acetate (DDAVP) were tested in vitro to evaluate the effect of the contained preservatives on drug permeation across rabbit nasal mucosa. Experiments were performed using Franz-type diffusion cells with rabbit nasal mucosa as model barrier. Transport profiles obtained in comparison with a preservative-free solution evidenced that in the presence of preservatives DDAVP permeation in vitro always increased (p<0.05), although at different extents (chlorobutanolAssuntos
Desamino Arginina Vasopressina/administração & dosagem
, Desamino Arginina Vasopressina/farmacocinética
, Mucosa Nasal/efeitos dos fármacos
, Mucosa Nasal/metabolismo
, Conservantes Farmacêuticos/farmacologia
, Ácido Sórbico/farmacologia
, Adjuvantes Farmacêuticos/farmacologia
, Administração Intranasal
, Animais
, Compostos de Benzalcônio/química
, Clorobutanol/química
, Difusão/efeitos dos fármacos
, Técnicas In Vitro
, Permeabilidade/efeitos dos fármacos
, Coelhos
, Equivalência Terapêutica