RESUMO
Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Queimaduras/tratamento farmacológico , Pirimidinas/uso terapêutico , Infecção da Ferida Cirúrgica/tratamento farmacológico , Adjuvantes Imunológicos/toxicidade , Animais , Avaliação Pré-Clínica de Medicamentos , Cobaias , Dose Letal Mediana , Camundongos , Complicações Pós-Operatórias/prevenção & controle , Pirimidinas/toxicidade , Coelhos , Ratos , Ratos Wistar , Cicatrização/efeitos dos fármacosRESUMO
The anti-inflammatory and analgesic action of diucifon, methyluracil and 4,4'-diaminodiphenylsulfone (DDS) was studied in comparison with some nonsteroid preparations. In three traditional models of agar, kaolin and carrageenan paw edema and in the models of analgesia (convulsions, induced by intraabdominal administration of acetic acid to mice and hyperalgesia according to Randall-Selitto's test in rats), diucifon proved more active than its precursors. In Randall-Selitto's test the efficiency of diucifon was 1.5 times less than that of butadione but 24 times higher than that of methyluracil; DDS had no analgetic activity. Diucifon, methyluracil and DDS did not exert any ulcerogenic action.