RESUMO
Phytochemical investigation of Semiaquilegia adoxoides was initiated in view of its common usage in traditional Chinese medicine and the scarcity of previous phytochemical studies. Fractionation of an ethanol extract from the roots of this plant led to the isolation and identification of a novel cyanogenic glycoside, 2-(beta-D-glucopyranosyloxy)-4-hydroxybenzeneacetonitrile (1). The structure of 1 was elucidated on the basis of IR, FAB-MS, 1D and 2D NMR spectral analysis.
Assuntos
Acetonitrilas/isolamento & purificação , Glicosídeos/isolamento & purificação , Semiaquilegia/química , Acetonitrilas/química , Cromatografia em Gel , Medicamentos de Ervas Chinesas/química , Glicosídeos/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Rotação Ocular , Raízes de Plantas/química , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria InfravermelhoRESUMO
Two new glycosidic quinoline alkaloids, 1-methyl-4-methoxy-8-(beta-D-glucopyranosyloxy)-2(1H)-quinolinone (1) and 4-methoxy-8-(beta-D-glucopyranosyloxy)-2(1H)-quinolinone (2), have been isolated from the 1-butanol extract of the aerial parts of Echinops gmelinii (Compositae). Structural elucidation of the two new glycoalkaloids was based on their 1H, 13C, DEPT, HSQC, COSY, HMBC NMR spectra and high-resolution FAB-MS data. These two compounds are rare examples of quinoline alkaloidal glycosides from natural sources.