RESUMO
Acute lung injury (ALI) is a clinically common critical disease with various treatment methods. Stem cell has drawn great attention for excellent performance in treatment of ALI. However, due to its high apoptosis rate, the further clinical application of stem cell is restricted. Exosomes are a kind of extracellular vesicles secreted by cells, which play important role in injury repair with further research about exosomes. This article reviews current situation, brief introduction to exosomes, repair effects of exosomes on ALI, and the potential signal pathway.
Assuntos
Lesão Pulmonar Aguda/metabolismo , Apoptose/efeitos dos fármacos , Exossomos/metabolismo , Lesão Pulmonar Aguda/diagnóstico , Terapia Biológica , Humanos , Medicina de Precisão , Transdução de Sinais , Células-TroncoRESUMO
The acute toxicity test in mice revealed no toxic effects after oral administration with mixed decoction of Radix Ginseng and Faeces Trogopterori. But a tendency of increasing toxicity was found with intraperitoneal injection. The subacute toxicity test in rats showed no obvious effect on white blood cell count (WBC), differential count (DC), platelet count (Pt), hemoglobin amount (Hb), serum glutamic pyruvic transaminase (SGPT), blood urea nitrogen (BUN), body weight (BW), and so on after oral administration with the above-said mixed decoction.