Pentacyclic Triterpene Profile and Its Biosynthetic Pathway in Cecropia telenitida as a Prospective Dietary Supplement.

Promising research over the past decades has shown that some types of pentacyclic triterpenes (PTs) are associated with the prevention of type 2 diabetes (T2D), especially those found in foods. The most abundant edible sources of PTs are those belonging to the ursane and oleanane scaffold. The principal finding is that Cecropia telenitida contains abundant oleanane and ursane PT types with similar oxygenation patterns to those found in food matrices. We studied the compositional profile of a rich PT fraction (DE16-R) and carried out a viability test over different cell lines. The biosynthetic pathway connected to the isolated PTs in C. telenitida offers a specific medicinal benefit related to the modulation of T2D. This current study suggests that this plant can assemble isobaric, positional isomers or epimeric PT. Ursane or oleanane scaffolds with the same oxygenation pattern are always shared by the PTs in C. telenitida, as demonstrated by its biosynthetic pathway. Local communities have long used this plant in traditional medicine, and humans have consumed ursane and oleanane PTs in fruits since ancient times, two key points we believe useful in considering the medicinal benefits of C. telenitida and explaining how a group of molecules sharing a closely related scaffold can express effectiveness.

Correlation between handgrip and isokinetic strength of shoulder muscles in elite sitting volleyball players.

The aim of this study was to examine the relationships between isometric handgrip (HG) strength and isokinetic strength data of the glenohumeral rotator muscles. Twelve (Female = 50%) Brazilian Sitting Volleyball (SV) national team players volunteered. Measures of maximal grip strength were obtained by a HG dynamometer Jamar® and isokinetic measures of peak torque (PT) and total work (TW) during shoulder rotations movements were obtained with a Biodex isokinetic dynamometer at speed of 60°/s and 180°/s. Pearson correlation coefficients between isometric HG and isokinetic strength data ranged between 0.23 and 0.72 for the PT and between 0.3 and 0.76 for the isokinetic TW. Results presented positive relationships between HG isometric strength and isokinetic strength of external rotators of the shoulder in SV players. We can suggest that in the absence of isokinetic dynamometers, HG isometric strength measurements could be used to measure strength levels of the external rotator muscles of elite SV players' shoulder, particularly in the TW values.

Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model.

Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.

Fundamental solutions to the bioheat equation and their application to magnetic fluid hyperthermia.

Methods of predicting temperature profiles during local hyperthermia treatment are very important to avoid damage to healthy tissue. With this aim, fundamental solutions of Pennes' bioheat equation are derived in rectangular, cylindrical, and spherical coordinates. The medium is idealised as isotropic with effective thermal properties. Temperature distributions due to space- and time-dependent heat sources are obtained by the solution method presented. Applications of the fundamental solutions are addressed with emphasis on a particular problem of Magnetic Fluid Hyperthermia (MFH) consisting of a thin shell of magnetic nanoparticles in the outer surface of a spherical solid tumour. It is observed from the solution of this particular problem that the temperature profiles are strongly dependent on the distribution of the magnetic nanoparticles within the tissue. An almost uniform temperature profile is obtained inside the tumour with little penetration of therapeutic temperatures to the outer region of healthy tissue. The fundamental solutions obtained can be used to develop boundary element methods to predict temperature profiles with more complicated geometries.

A inserção da regulamentação da profissão na área de Educação Física, dez anos depois: embates, debates e perspectivas / La inserción de la regulación de la profesión en el área de la educación física, diez años después: embates, debates y perspectivas / The insertion of the regulation of the profession in the area of physical education, ten years later: perspectives, strike and debates

Este texto discute alguns aspectos da regulamentação da profissão na área da Educação Física, seu desenvolvimento e a participação dos principais sujeitos políticos. Frente a um tema atual e polêmico, procura-se fazer uma apresentação objetiva e abrangente do seu desenvolvimento e ilustrar as posições e os argumentos dos sujeitos que participam do debate. Para tanto, inicia-se apresentando aspectos importantes da regulamentação das profissões, para depois elaborar uma análise da lei e resoluções do Conselho destacando: (a) o seu significado; (b) atribuições e competências; (c) o limite para a fiscalização e do poder de policia e (d) apontar as atividades típicas do profissional. A título de fechamento, descreve-se aspectos de uma polêmica bastante recente, a subordinação da dança, da yoga e das artes marciais ao Conselho Federal de Educação Física.

This text argues some questions controversies on the regulation of the profession. Our interest is to give a theoretical basement of a side, and to hear the citizens directly related on these controversies of another one. For this we first decide to clarify the initial aspects of the regulation of the professions, stops later making an analysis of the law and resolutions of the Advice presenting: (a) the meaning; (b) attributions and abilities; (c) the limit for the fiscalization and of the power of polices and (d) to point the typical activities of the professional. Concluded this part we will raise an controversial subject that appeared in these last five years: the subordination of the dance, yoga, martial arts to the Federal Advice of Physical Education.

Este texto discute las controversias sobre la regulación de la profesión. Nuestro interés es dar un suporte teórico de un lado, y oír a los ciudadanos relacionados directamente en estas controversias de otro. Para esto primero, decidimos clarificar los aspectos iniciales de la regulación de las profesiones, un análisis de la ley y de las resoluciones del consejo: (a) el significado; (b) atribuciones y capacidades; (c) el límite para el fiscalización y poder de policía y (d) señalar las actividades típicas del profesional. Después de esta parte levantaremos un tema polémico: la subordinación de la danza, yoga, artes marciales al Consejo Federal de la Educación Física.

Weight gain in preterm infants following parent-administered Vimala massage: a randomized controlled trial.

Massage has been proposed as a way of facilitating development and growth of newborns through its effects on increasing blood flow, heart rate, digestion, and immunity. Massage might increase basal metabolism and nutrient absorption through endocrine effects such as increase in insulin and adrenaline and decrease in cortisol. Preliminary studies have suggested significant impact on weight gain with shortening of in-hospital stays of up to 6 days. We compared weight gain among preterm infants receiving Vimala massage plus usual care versus usual care alone. A randomized controlled trial was conducted. Sixty clinically stable preterm newborns with a corrected gestational age of 30 to 35 weeks receiving enteral nutrition in the hospital nursery were included. Half of them were assigned at random to receive Vimala massage twice daily for 10 days plus usual nursery care; the others received usual nursery care. Weight, head circumference, caloric intake, and nutritional method were recorded daily. Group characteristics were compared with analysis of variance, T test, and chi (2) test as appropriate. There were no differences between groups in gender, gestational age, initial weight, head circumference, and caloric intake and type of nutrition at baseline. Infants receiving massage had a larger weight gain versus the control group since the third day (188.2 +/- 41.20 g/kg versus 146.7 +/- 56.43 g/kg, P < 0.001). Hospital stay was shorter in infants receiving massage and usual nursery care (15.63 +/- 5.41 days versus 19.33 +/- 7.92 days, P = 0.03). The addition of parent-administered Vimala massage to usual nursery care resulted in increased weight gain and shorter hospital stay among clinically stable preterm newborns.