RESUMO
Objective: In Chinese herbal medicine (CHM) history, Lonicerae Japonicae Flos and Lonicerae Flos were used clinically as one drug, but now they are admitted as two herbal medicines in Chinese Pharmacopoeia (2010 edition). This study used network pharmacology to investigate whether the two can be used interchangeably for the treatment of inflammatory diseases in TCM clinical practice. Methods: Lonicerae Japonicae Flos and Lonicerae Flos were compared in the inflammation mechanism including core targets, Gene Ontology (GO), pathway and principle chemical components by the method of network pharmacology. Results: Lonicerae Japonicae Flos and Lonicerae Flos shared in six targets accounting for 66.7% of the entire core targets and more than half of the GO terms and pathways are similar. Organic acids are dominent compounds responsible for anti-inflammatory effects. Three of the compounds that bind to core targets including luteolin, quercetin and kaempferol, are shared in both herbs. Conclusion: Due to high similarity between Lonicerae Japonicae Flos and Lonicerae Flos, we believe that they can be used interchangeably for the inflammation in clinical treatment.
RESUMO
Cathepsin S is a cysteine protease which is closely related to autoimmune diseases,psoriasis and other diseases. In this study,we used virtual screening method to screen compounds,which from the natural product library of traditional Chinese medicine,with potential inhibitory effect on cathepsin S. The work involved in study on inhibitory mechanism of representative compounds,then analysis of the distribution of these compounds in traditional Chinese medicine and the correlation with disease,so as to provide a new drug research and data-base for cathepsin S. The complex crystal structure of cathepsin S,2FQ9,was used to establish the pharmacophore model of cathepsin S inhibitor,and the best pharmacophore model was selected. As a result,fifty compounds were selected from TCMD database. After molecular docking,65 potential inhibitors were identified. Potential inhibitors can produce multiple intermolecular interactions with targets,resulting in inhibition. There are 58 kinds of traditional Chinese medicines which include 65 natural inhibitors. Data collection and analysis of the nature,flavor xing,channel entry and modern pharmacological effects of these traditional Chinese medicines showed that most of them were related to the biological activity of cathepsin S,which supported the validity of the screening results. Cathepsin S has a certain correlation with autoimmune diseases and can be used as a target for further study of traditional Chinese medicine.
Assuntos
Catepsinas , Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Simulação de Acoplamento MolecularRESUMO
The function of health care and rehabilitation in Tai Chi has been recognized by the world.Studies on the mechanism of health care in Tai Chi have been conducted by domestic and international experts using the methods of sports biomechanics,most of which focus on human lower extremity.Twenty research literatures (15articles in English and 5 articles in Chinese) during the year 2007-2015 about biomechanics of the lower extremity in Tai Chi were searched.According to the research purpose and evaluation index,this paper mainly reviewed from 3 aspects:the kinematic & kinetic characteristics of Tai Chi and its influence on the lower extremity,the effect of Tai Chi on muscle activity of the lower extremity,and the impact of Tai Chi movement on interaction between biomechanical parameters of the lower extremity and other system parameters.The prospects and limitations in biomechanical studies on the lower extremity in Tai Chi were also summarized.
RESUMO
The function of health care and rehabilitation in Tai Chi has been recognized by the world.Studies on the mechanism of health care in Tai Chi have been conducted by domestic and international experts using the methods of sports biomechanics,most of which focus on human lower extremity.Twenty research literatures (15articles in English and 5 articles in Chinese) during the year 2007-2015 about biomechanics of the lower extremity in Tai Chi were searched.According to the research purpose and evaluation index,this paper mainly reviewed from 3 aspects:the kinematic & kinetic characteristics of Tai Chi and its influence on the lower extremity,the effect of Tai Chi on muscle activity of the lower extremity,and the impact of Tai Chi movement on interaction between biomechanical parameters of the lower extremity and other system parameters.The prospects and limitations in biomechanical studies on the lower extremity in Tai Chi were also summarized.
RESUMO
The function of health care and rehabilitation in Tai Chi has been recognized by the world. Studies on the mechanism of health care in Tai Chi have been conducted by domestic and international experts using the methods of sports biomechanics, most of which focus on human lower extremity. Twenty research literatures (15 articles in English and 5 articles in Chinese) during the year 2007-2015 about biomechanics of the lower extremity in Tai Chi were searched. According to the research purpose and evaluation index, this paper mainly reviewed from 3 aspects: the kinematic & kinetic characteristics of Tai Chi and its influence on the lower extremity, the effect of Tai Chi on muscle activity of the lower extremity, and the impact of Tai Chi movement on interaction between biomechanical parameters of the lower extremity and other system parameters. The prospects and limitations in biomechanical studies on the lower extremity in Tai Chi were also summarized.
RESUMO
The compound that distributes in the herbs with one common effect was named as "co-effect compound" (CEC). The CECs of three traditional Chinese medicine(TCM) effects, purgative, relieving pain and clearing heat, had been found and studied. A strong corresponding relationship was found between the pharmacological activities of CECs and the TCM effect they belong to. The study shows that it may be a feasible method to connect traditional effect of TCM with modem pharmacological activity.