RESUMO
Diarrhea is a common clinical digestive tract disease, and the second major cause of illness and death among children. At present, long-term irrational use of chemical drugs and antibiotics in the treatment of diarrhea will accelerate the emergence of drug resistance of intestinal pathogenic bacteria, and modern drug preparations and therapies cost very high, which therefore bring difficulties to clinical treatment. As a pure natural drug containing a variety of active ingredients, traditional Chinese medicine(TCM) has the advantages of low residue, low toxicity and low drug resistance. And the study shows that TCM preparations, single TCM and effective components of TCM have a unique efficacy in the treatment of diarrhea, which makes anti-diarrhea TCM become a hotspot in the research field of anti-diarrhea drugs. Therefore, through consultation of relevant Chinese and foreign literatures in recent years, this study summarizes relevant anti-diarrhea TCM, and systematically expounds the treatment of diarrhea with TCM in the aspects of regulating the balance of water and electrolyte, anti-inflammation, interfering with gastrointestinal hormone secretion, protecting intestinal mucosa, promoting intestinal repair. Specifically, because the excessive secretion and absorption of liquids and electrolytes by intestinal epithelial cells are two important factors in the pathogenesis of diarrhea, the reduction of intestinal fluid secretion and the promotion of intestinal fluid absorption become effective means for the treatment of diarrhea. This paper reviews the effects and mechanisms of TCM against diarrhea, in order to provide theoretical support for the study of the anti-diarrhea mechanism and the research and development of new drugs of TCM against diarrhea.
RESUMO
Comparative state is one of the basic thinking methods of TCM, and widely used in dermatology. For complicated and repeated psoriasis with blood stasis, comparative state method can be applied to direct differentiation of syndrome, and guide the analysis on etiology and pathogenesis to establish treatment methods, which can provide new ideas for TCM treatment of psoriasis.
RESUMO
Taking application of some isolation and purification technologies, including crushing, solvent extraction, preliminary solvent isolation, column chromatographies over silica gel and Sephadex LH-20 gel and preparative HPLC, 8 compounds were obtained from the seeds of Jufeng grape sourced from market. Their structures were identified by spectroscopic methods and comparison with literature values as Catechin (1), Epicatechin (2), quercetin (3), ethylgallate (4), rel-(2S, 3R) -2-(4-hydroxy-3-methoxyphenyl) -3- (hydroxymethyl)-5-(3-hydroxypropyl)-2,3-dihydrobenzofuran-7-ol (5), rel-(2α, 3β)-7-O-methylcedrusin (6), rel-(1R,2S)-1-(4-hydroxy-3-methoxyphenyl) -2-(4-(3-hydroxypropyl) -2-methoxyphenoxy) propane-1,3-diol (7), and (+) -isolariciresinol (8), respectively. Compounds 5-8 were serial lignans isolated from the seeds of grape for the first time. Structurally, 5 and 6 belong in benzofuran-8,3'-neolignans, 7 in 8,4'-oxyneolignan, and 8 in 8,8' :2,7'-cyclolignan. According to in vitro activity evaluation conducted in cell model, compound 6 showed significant anti-oxidative ability, with the activity of RAW264. 7 cell superoxide dismutase being raised evidently in the test as compared with the positive anti-oxidative agents, compounds 1 and 2.