RESUMO
A new prenylated flavone, named artoindonesianin L (1), was isolated from Artocarpus rotunda (Hout) Panzer (Moraceae). Its structure was elucidated as on the basis of spectroscopic evidence. Along with this new compound, four known phenolic compounds were also isolated from this plant and identified as artonins M (2) and E (3), cycloartobiloxanthone (4) and artonin O (5). All these compounds showed significant cytotoxicity against murine P388 leukemia cells.
Assuntos
Antineoplásicos/farmacologia , Flavonoides/farmacologia , Moraceae , Fitoterapia , Extratos Vegetais/farmacologia , Animais , Antineoplásicos/uso terapêutico , Flavonoides/uso terapêutico , Concentração Inibidora 50 , Camundongos , Extratos Vegetais/uso terapêutico , Raízes de Plantas , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
Three new isoprenylated flavones, artoindonesianins G-I (1-3), together with the two known flavones artelastofuran (4) and artelasticin (5), have been isolated from the heartwood of Artocarpus lanceifoliu. The structures of the new compounds were determined on the basis of spectroscopic data. Compounds 1-3 and 5 showed strong cytotoxicity against P-388 cells.
Assuntos
Flavonoides/toxicidade , Moraceae , Fitoterapia , Extratos Vegetais/toxicidade , Flavonoides/química , Humanos , Espectroscopia de Ressonância Magnética , Extratos Vegetais/química , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
A new stilbene dimer, andalasin A (1), together with the known stilbene oxyresveratrol and the 2-arylbenzofuran glycoside mulberroside C, have been isolated from the wood of Morus macroura. The structure of the new compound was elucidated on the basis of spectroscopic data. Compound 1 shows weak antinematodal and moderate antifungal properties.
Assuntos
Medicamentos de Ervas Chinesas/química , Plantas Medicinais/química , Estilbenos/química , Dimerização , HumanosRESUMO
A new xanthone derivative, artoindonesianin C (1), was isolated from Artocarpus teysmanii, together with two known prenylated flavonoids, cycloartobiloxanthone and artonin J. The structure of artoindonesianin C (1) was determined on the basis of MS and NMR evidence and by comparison with known related compounds.
Assuntos
Flavonoides/isolamento & purificação , Plantas Medicinais/química , Animais , Artemia , Bombyx , Flavonoides/química , Flavonoides/farmacologia , Técnicas In Vitro , Dose Letal Mediana , Leucina/metabolismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Microvilosidades/efeitos dos fármacos , Microvilosidades/metabolismo , Epiderme Vegetal/química , Raízes de Plantas/química , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Two new prenylated flavones, named artoindonesianin A (1) and artoindonesianin B (2), were isolated from the root of Artocarpus champeden, together with a known prenylated flavone, artonin A. The structures of artoindonesianins A and B were determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1 and 2 exhibited cytotoxic activity against murine leukemia (P-388) cells.