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Drug Res (Stuttg) ; 70(4): 123-130, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32110820

RESUMO

Herbal medicines therapy is appreciated by many research works because herbal drugs have relatively high therapeutic window, lower side effects and more cost effective. Guggulipid is an ethyl acetate extract of resin known as guggul from the tree Commiphora wightii / mukul (Arn.) Bhandari. Chemical analysis revealed that the compounds responsible for the major activities of gum guggul are the isomers E- and Z-guggulsterone. Guggul has been used for thousands of years in the treatment of arthritis, inflammation, obesity, cardiac protection, anti-ulcer, anti-epileptic and disorders of lipid metabolism. This review is an assortment of available information reported on its chemical, pharmacological and toxicological properties in various research studies. The available therapeutic properties of guggulipid make it suitable natural product for the treatment of various disorders like inflammation, pain, wounds, liver disorder and Acne etc. Graphical Abstract Graphical Abstract.


Assuntos
Extratos Vegetais/uso terapêutico , Gomas Vegetais/uso terapêutico , Pregnenodionas/farmacologia , Acne Vulgar/tratamento farmacológico , Artrite/tratamento farmacológico , Commiphora , Epilepsia/tratamento farmacológico , Humanos , Inflamação/tratamento farmacológico , Transtornos do Metabolismo dos Lipídeos/tratamento farmacológico , Hepatopatias/tratamento farmacológico , Obesidade/tratamento farmacológico , Dor/tratamento farmacológico , Úlcera Péptica/tratamento farmacológico , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Gomas Vegetais/química , Gomas Vegetais/farmacologia , Pregnenodionas/química , Estereoisomerismo
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