RESUMO
In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 µ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 µ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.
Assuntos
Acetilcolinesterase/efeitos dos fármacos , Burseraceae/química , Leishmania/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Inibidores da Colinesterase/química , Humanos , Leishmania/enzimologia , Leishmaniose/tratamento farmacológico , Leishmaniose/parasitologia , Extratos Vegetais/química , Folhas de Planta/química , Floresta Úmida , Escopoletina/administração & dosagemRESUMO
The tumour-inhibitory effect of an ethanolic extract of chicory root was studied against Ehrlich ascites carcinoma in mice; significant results were obtained at doses from 300 to 700 mg/kg.