Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Mais filtros

Medicinas Complementares
Métodos Terapêuticos e Terapias MTCI
Base de dados
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
Bioengineered ; 14(1): 165-178, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37377392

RESUMO

To establish a standard Traditional Chinese medicine (TCM) bone setting technique, standardize the operation and inherit the TCM bone setting technique. This project was based on the interactive tracking of bone setting techniques with a dedicated position tracker, the motion tracking of bone setting techniques based on RGBD (Red Green Blue Depth) cameras, the digital analysis of bone setting techniques, and the design of the virtual reality platform for bone setting techniques. These key technical researches were combined to construct an interactive bone setting technique. The virtual simulation system can reproduce the implementation process of the expert's bone setting technique. The user can observe the implementation of the manipulative technique from multiple angles; through human-computer interaction, the whole process of implementation of the bone setting technique can be simulated, and the movement and reduction of the affected bone can be observed at the same time. It can be used as a teaching and training system for assisting bone setting techniques. Students can use the system to carry out repeated self-training, and can instantly compare with the standard techniques of the expert database, breaking the traditional teaching mode of 'expected and unspeakable' and avoid directly using patients. Therefore, this research makes it possible to reduce teaching costs, reduce risks, improve teaching quality, and make up for the lack of teaching conditions. It is very positive for the inheritance of the traditional Chinese 'intangible culture' of bone setting techniques, and to promote the digitalization and standardization of bone setting techniques.


Using computer technology to digitally record bone-setting manipulations.Construct a virtual simulation system for interactive bone-setting manipulation.Promote the digitization and standardization of bone-setting techniques.


Assuntos
Realidade Virtual , Humanos , Simulação por Computador , Medicina Tradicional Chinesa , Computadores
2.
J Cell Physiol ; 234(4): 4267-4276, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30146787

RESUMO

Identification of natural compounds that inhibit osteoclastogenesis will facilitate the development of antiresorptive treatment of osteolytic bone diseases. Asiaticoside is a triterpenoid derivative isolated from Centella asiatica, which exhibits varying biological effects like angiogenesis, anti-inflammation, wound healing, and osteogenic differentiation. However, its role in osteoclastogenesis remains unknown. Here, we show that Asiaticoside can suppress RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner. Asiaticoside attenuated the expression of osteoclast marker genes including Ctsk, Atp6v0d2, Nfatc1, Acp5, and Dc-stamp. Furthermore, Asiaticoside inhibited RANKL-mediated NF-κB and NFATc1 activities, and RANKL-induced calcium oscillation. Collectively, this study demonstrates that Asiaticoside inhibited osteoclast formation and function through attenuating RANKL-induced key signaling pathways, which may indicate that Asiaticoside is a potential antiresorptive agent against osteoclast-related osteolytic bone diseases.


Assuntos
Centella/química , Macrófagos/efeitos dos fármacos , NF-kappa B/metabolismo , Fatores de Transcrição NFATC/metabolismo , Osteoclastos/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Ligante RANK/farmacologia , Triterpenos/farmacologia , Animais , Sinalização do Cálcio , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Regulação da Expressão Gênica , Macrófagos/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Fatores de Transcrição NFATC/genética , Osteoclastos/metabolismo , Fosforilação , Proteínas Proto-Oncogênicas c-fos/metabolismo , Células RAW 264.7 , Triterpenos/isolamento & purificação
3.
Zhongguo Gu Shang ; 23(7): 530-3, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20701131

RESUMO

OBJECTIVE: Using the method of bleeding from the orbital vein and lancing to make the animal model of trauma, and to observe the influence of reinforcing Qi strength spleen in the expression of bFGF and EGF in the reparative process of raw surface, in order to explore the possible mechanism of reinforcing Qi strength spleen in promoting the rehabilitation of soft tissue. METHODS: Forty healthly adult SD rats were made to be traumatic model using the method of bleeding from the orbital vein and lancing. After operation, there were 33 rats survival, which were divided into the reinforcing Qi strength spleen group, the activating blood circulation to dissipate blood stasis group and the model group randomly. The raw surface and ambient normal skin were taken at the 3rd, 7th and 14th days after operation to detect the expression of bFGF and EGF by immunohistochemical method. RESULTS: At the 3rd, 7th and 14th days after operation, the expression of bFGF and EGF in the tissue of raw surface of the reinforcing Qi strength spleen group and the activating blood circulation to dissipate blood stasis group was obviously higher than that of the model group(P < 0.05). Compared with the activating blood circulation to dissipate blood stasis group, the expression of bFGF and EGF in the tissue of raw surface of the reinforcing Qi strength spleen group was higher (P < 0.05) in the 3rd and 7th day after operation. But in the 14th after operation, there was no significantly difference between reinforcing Qi strength spleen group and activating blood circulation to dissipate blood stasis group. CONCLUSION: The method of reinforcing Qi strength spleen can efficiently promote the expression of bFGF and EGF in raw surface of serious soft tissue injury.


Assuntos
Medicamentos de Ervas Chinesas/administração & dosagem , Fator de Crescimento Epidérmico/genética , Fator 2 de Crescimento de Fibroblastos/genética , Expressão Gênica/efeitos dos fármacos , Lesões dos Tecidos Moles/tratamento farmacológico , Baço/fisiopatologia , Animais , Modelos Animais de Doenças , Fator de Crescimento Epidérmico/metabolismo , Feminino , Fator 2 de Crescimento de Fibroblastos/metabolismo , Humanos , Masculino , Qi , Ratos , Ratos Sprague-Dawley , Lesões dos Tecidos Moles/genética , Lesões dos Tecidos Moles/metabolismo , Lesões dos Tecidos Moles/fisiopatologia , Baço/efeitos dos fármacos
4.
Zhongguo Gu Shang ; 21(9): 664-6, 2008 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-19105275

RESUMO

OBJECTIVE: To study the effects of Chinese drugs based on strengthening the spleen and replenishing qi treatment rule on neoformative capillaries and fibroblast during the soft tissue repair after serious trauma in rats, so as to explore the biological basis of the TCM theory "the spleen dominate extremities and muscles" applied to the treatment of soft tissue injuries. METHODS: The model rats were established by bleeding from femoral artery and lancing method, and the rats were randomly divided into the control group, strengthening the spleen group and activating blood and resolving stasis group. The samples were got from the tissue of the wounded area at the 5th, 10th and 15th days after oral administration of the traditional Chinese medicine. After fixation and section, the tissues were stained by CD31 and PCNA staining. The amount of the capillaries and fibroblasts in the tissue of the wounded area were observed through multi-purpose microscope (ZEISS Axioskop2). Quantitative analysis was carried out on Image-ProPlus image analyzer. RESULTS: The amount of the capillaries and fibroblasts in the wounded tissue in the strengthening the spleen group were larger than that in the control group at the 5th, 10th and 15th day. And the proliferation speed of capillaries and fibroblasts was faster than those in the control group or the activating blood and resolving stasis group. CONCLUSION: The Chinese drugs according to strengthening the spleen and replenishing qi treatment rule were effective to promote growth of the granulation tissue and facilitate healing of the wounded area. And it has better effect than the treatment of promoting blood circulation and removing stasis.


Assuntos
Qi , Lesões dos Tecidos Moles/fisiopatologia , Lesões dos Tecidos Moles/terapia , Baço/fisiologia , Animais , Capilares/patologia , Contagem de Células , Proliferação de Células , Feminino , Fibroblastos/patologia , Masculino , Ratos , Lesões dos Tecidos Moles/patologia , Cicatrização
5.
Zhen Ci Yan Jiu ; 33(2): 98-102, 2008 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-18630584

RESUMO

OBJECTIVE: To observe the effect of electroacupuncture (EA) on learning-memory ability of vascular dementia (VD) rats, and the simultaneous changes of plasma and cerebral somatostatin (SS) and beta-endorphin (EP) contents. METHODS: Forty-one SD rats were randomly divided into control (n=8), model A (n=8, no treatment) and B (n=8, intragastric perfusion of 15% saline), EA (n=9) and medication (n=8, intragastric perfusion of Nimoldipine, 12 mg/kg) groups. VD model was established by using modified 4-vessels occlusion method. EA (150 Hz, 1-2 mA) was applied to "Baihui" (GV 20), "Dazhui" (DU 14), "Pishu" (BL 20) and "Shenshu" (BL 23) for 20 min, once daily for 15 days. Morris water maze tests were conducted for evaluating the rats' learning-memory ability. The contents of SS and beta-EP in plasma and brain tissue were measured by radioimmunoassay (RIA). RESULTS: In comparison with sham-operation group, the escape latency (EL) prolonged significantly and the target-platform crossing times decreased remarkably (P<0.01) in model group B. In comparison with model group B, EL shortened and target-platform crossing times increased both significantly in EA and medication groups (P<0.01). Plasma and cerebral SS, and cerebral beta-EP contents of model groups A and B were significantly lower than those of sham-operation group(P<0.01), while plasma beta-EP level had no obvious change (P>0.05). Plasma and cerebral SS, and cerebral beta-EP contents in both EA and medication groups were considerably higher than those in model groups A and B (P<0.01). No significant differences were found between EA and medication groups in EL, target-platform crossing times, plasma and cerebral SS and beta-EP levels, and between model group A and model group B in plasma and cerebral SS and beta-EP levels (P>0.05). CONCLUSION: EA can raise plasma and cerebral SS and cerebral beta-EP levels, and improve the learning-memory ability in VD rats.


Assuntos
Química Encefálica , Demência Vascular/terapia , Eletroacupuntura , Aprendizagem , Memória , Somatostatina/análise , beta-Endorfina/análise , Pontos de Acupuntura , Animais , Demência Vascular/metabolismo , Demência Vascular/psicologia , Masculino , Ratos , Ratos Sprague-Dawley , Somatostatina/sangue , beta-Endorfina/sangue
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA