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1.
Eur J Neurol ; 20(4): 616-22, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22672698

RESUMO

BACKGROUND AND PURPOSE: To investigate the risk of stroke development following a diagnosis of Bell's palsy in a nationwide follow-up study. METHODS AND MATERIALS: Information on Bell's palsy and other factors relevant for stroke was obtained for 433218 eligible subjects without previous stroke who had ambulatory visit in 2004. Of those, 897 patients with Bell's palsy were identified. Over a median 2.9 years of follow-up, 4581 incident strokes were identified. We estimated hazard ratios (HR) and 95% confidence intervals [CI] with Cox proportional hazard models adjusting for age, sex, co-morbidities, and important risk factors. Standardized incidence ratio of stroke amongst patients with Bell's palsy was analyzed. RESULTS: Compared with non-Bell's palsy patients, patients with Bell's palsy had a 2.02-times (95% CI, 1.42-2.86) higher risk of stroke. The adjusted HR of developing stroke for patients with Bell's palsy treated with and without systemic steroid were 1.67 (95% CI, 0.69-4) and 2.10 (95%, 1.40-3.07), respectively. CONCLUSIONS: Patients with Bell's palsy carry a higher risk of stroke than the general population. Our data suggest that these patients might benefit from a more intensive stroke prevention therapy and regular follow-up after initial diagnosis.


Assuntos
Paralisia de Bell/complicações , Paralisia de Bell/tratamento farmacológico , Esteroides/uso terapêutico , Acidente Vascular Cerebral/complicações , Adulto , Paralisia de Bell/epidemiologia , Diabetes Mellitus/epidemiologia , Determinação de Ponto Final , Feminino , Seguimentos , Humanos , Hipertensão/complicações , Hipertensão/epidemiologia , Classificação Internacional de Doenças , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Programas Nacionais de Saúde/estatística & dados numéricos , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Risco , Fatores Sexuais , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/mortalidade , Análise de Sobrevida , Taiwan/epidemiologia
2.
Arch Androl ; 52(2): 117-21, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16443588

RESUMO

The aim of the study was to report our experiences in the treatment of chronic prostatitis using combination regimen including ciprofloxacin, doxazosin, allopurinol and biofeedback perineal massage. From May 2003 to April 2004, 7 patients with NIH Category II-chronic bacterial prostatitis and 7 patients with NIH Category IIIA-inflammatory chronic pelvic pain syndrome were treated. The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was scored by the patient before and after the treatment, 6 months later. In Category II patients, the bacterial eradication rate was 71% after ciprofloxacin treatment during a follow-up of 6 months. The beneficial response rate to allopurinol, doxazosin and biofeedback perineal massage was 50%, 42% and 85%, respectively. In NIH Category IIIA patients, the individual beneficial response rate to ciprofloxacin, allopurinol, doxazosin and biofeedback perineal massage was 57%, 100%, 71% and 100%, respectively. Comparing pre-treatment and post-treatment results of the combination regimen, there was a statistically significant improvement in the 3 domains of pain score, urinary symptoms and quality of life impact of the NIH-CPSI. Combination regimen including ciprofloxacin, doxazosin allopurinol and biofeedback perineal massage in the treatment of chronic prostatitis is a safe and effective modality in our limited experience.


Assuntos
Prostatite/terapia , Antagonistas Adrenérgicos alfa/uso terapêutico , Adulto , Idoso , Alopurinol/uso terapêutico , Antibacterianos/uso terapêutico , Ciprofloxacina/uso terapêutico , Terapia Combinada , Doxazossina/uso terapêutico , Quimioterapia Combinada , Supressores da Gota/uso terapêutico , Humanos , Masculino , Massagem , Pessoa de Meia-Idade , Prostatite/tratamento farmacológico
3.
Br J Dermatol ; 149(3): 647-52, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14511004

RESUMO

We describe a new method for treating livedoid vasculopathy. The typical presentation of livedoid vasculopathy includes chronic, recurrent painful ulcers, satellite scar-like atrophy and telangiectasia involving the lower extremities. Histologically, these lesions show areas of ulceration and dermal vessel occlusion without frank inflammatory cell infiltration. There is currently no satisfactory therapy available for this disease. Hyperbaric oxygen (HBO) has recently established itself as one of the most effective methods of treating ischaemic wounds, including diabetic ulcers. We used this therapy in two patients whose lesions were resistant to multiple therapeutic modalities. Not only did their ulcers respond rapidly to the HBO therapy, but the disturbing wound pain also resolved at the same time. To our knowledge, this is the first successful trial of HBO therapy in livedoid vasculopathy. We believe this to be a very promising new therapy for livedoid vasculopathy and to be worth further investigation.


Assuntos
Oxigenoterapia Hiperbárica/métodos , Úlcera da Perna/terapia , Transtornos da Pigmentação/terapia , Púrpura/terapia , Dermatopatias Vasculares/terapia , Adolescente , Adulto , Doença Crônica , Feminino , Humanos , Masculino , Dor/etiologia , Dor/prevenção & controle
4.
BJU Int ; 89(9): 955-60, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12010247

RESUMO

OBJECTIVE: To identify genes that are affected by vascular endothelial growth factor (VEGF), as an intracavernosal injection with VEGF improved the recovery of erectile function in a rat model of arteriogenic impotence, specifically examining the three nitric oxide synthase (NOS) genes, nNOS, eNOS, and iNOS. MATERIALS AND METHODS: Male rats had their pudendal arteries ligated or underwent a sham operation. They were then treated by an intracavernosal injection with 4 microg of VEGF in phosphate-buffered saline (PBS) or PBS alone. At 6 and 24 h after treatment electrostimulation was applied to the cavernosal nerve and the intracorporal pressure measured. The erectile tissue was then harvested for RNA isolation and cryo-sectioning. The isolated RNA was used for microarray and reverse transcription-polymerase chain reaction (RT-PCR) analyses, and the tissue sections for immunohistochemical analysis. RESULTS: Microarray analysis detected nNOS, eNOS and iNOS at very low expression levels in PBS-treated rats; expression levels were higher for eNOS and iNOS in all VEGF-treated rats. These results were further confirmed by RT-PCR analysis. Immunohistochemical analysis identified the cavernosal endothelium and smooth muscle as the tissue types where eNOS and iNOS were up-regulated, respectively. CONCLUSIONS: This is the first report of the induction of both eNOS and iNOS in the penis after intracavernosal VEGF. These events may help support a significant recovery of erectile function after interrupting the blood supply to the penis.


Assuntos
Proteínas de Transporte/metabolismo , Fatores de Crescimento Endotelial/farmacologia , Óxido Nítrico Sintase/metabolismo , Animais , Proteínas de Transporte/genética , Fatores de Crescimento Endotelial/administração & dosagem , Imuno-Histoquímica/métodos , Impotência Vasculogênica/enzimologia , Injeções , Masculino , Óxido Nítrico Sintase/genética , Óxido Nítrico Sintase Tipo II , Pênis/efeitos dos fármacos , RNA Mensageiro/metabolismo , Ratos , Ratos Sprague-Dawley , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Ubiquitina-Proteína Ligases , Fator A de Crescimento do Endotélio Vascular
5.
Biochem Biophys Res Commun ; 285(2): 565-9, 2001 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-11444882

RESUMO

Penile arterial insufficiency is one of the most common causes of ED. We have established a traumatic arteriogenic insufficiency rat model by the ligation of the pudendal arteries. To simulate both acute and chronic traumatic injuries, five ligation periods (6 h, 3 days, 7 days, 3 weeks, and 6 weeks) were chosen. By electrostimulation of the cavernous nerve, the intracavernous pressure was determined to be between 20 and 40-cm H(2)O for the ligated rats compared to around 100-cm H(2)O for the control rats. The erectile tissue in the corpus cavernosum of these rats was then subjected to microarray analysis, in which an array that contains cDNA fragments representing 1176 rat genes was used. The results demonstrated that normal rat corpus cavernosum expressed approximately 200 genes at detectable levels and that ligation produced differential expression of approximately 25 genes, depending on the duration of ligation. The most highly ligation-induced gene was apolipoprotein D (ApoD), with peak expression in the 3- and 7-day ligated rats. Three of the insulin-like growth factor binding proteins (IGFBP-1, 3, and 5) were upregulated in all ligated rats. IGFBP-6, which was one of the most highly expressed genes in the normal corpus cavernosum, was down-regulated in all ligated rats. Cysteine proteases of the cathepsin family were also differentially expressed between control and ligated rats, with cathepsin K being down-regulated most. A few genes were upregulated only in the 6-week ligated rats, including angiotensin-converting enzyme. Finally, VEGF, whose induction has been identified in many other ischemic tissues, was not induced in corpus cavernous tissue of ligated rats.


Assuntos
Perfilação da Expressão Gênica , Regulação da Expressão Gênica/fisiologia , Impotência Vasculogênica/genética , Proteínas/genética , Animais , Apolipoproteínas/genética , Apolipoproteínas D , Modelos Animais de Doenças , Estimulação Elétrica , Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina/genética , Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/genética , Proteína 5 de Ligação a Fator de Crescimento Semelhante à Insulina/genética , Proteína 6 de Ligação a Fator de Crescimento Semelhante à Insulina/genética , Masculino , Pênis/inervação , Ratos , Ratos Sprague-Dawley , Reação em Cadeia da Polimerase Via Transcriptase Reversa
6.
Am J Chin Med ; 28(2): 227-38, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10999441

RESUMO

Berberine is an alkaloid occurring in the plant genera Berberis and Coptis. Although berberine had been demonstrated to have antineoplastic function by inhibiting DNA-synthesis in activated lymphocytes, there is no available information to address berberine affects on human leukemia cell N-acetyltransferase (NAT) activity and 2-aminofluorene (AF)-DNA adduct formation. Thus, berberine was tested for inhibition of arylamine NAT activity and AF-DNA adduct formation in human leukemia cells. The NAT activity was measured by a high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and the remaining AF and p-aminobenzoic acid (PABA). The NAT activity and AF-DNA adduct formation in human leukemia cells were inhibited by berberine in a dose-dependent manner, i.e. the higher the concentration of berberine, the higher the inhibition of NAT activity and AF-DNA adduct. The data also indicate that berberine decreased the apparent values of Km and Vmax from human leukemia cells in both cytosol and intact cells.


Assuntos
Antineoplásicos/farmacologia , Arilamina N-Acetiltransferase/efeitos dos fármacos , Berberina/farmacologia , Carcinógenos/metabolismo , Adutos de DNA/efeitos dos fármacos , Fluorenos/metabolismo , Leucemia Mieloide/metabolismo , Carcinógenos/química , Adutos de DNA/química , Medicamentos de Ervas Chinesas/farmacologia , Fluorenos/química , Células HL-60/efeitos dos fármacos , Células HL-60/enzimologia , Células HL-60/metabolismo , Humanos , Leucemia Mieloide/enzimologia , Leucemia Mieloide/patologia
7.
J Appl Toxicol ; 19(2): 75-81, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10215179

RESUMO

Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene (2-AF) were determined in the bacterium Klebsiella pneumoniae. Cytosols or suspensions of K. pneumoniae with or without specific concentrations of diallyl sulphide (DAS) or diallyl disulphide (DADS) as co-treatment showed different percentages of 2-AF acetylation. The data indicated that there was decreased NAT activity associated with increased levels of DAS or DADS in K. pneumoniae. In growth studies on K. pneumoniae it was demonstrated that DAS or DADS elicited a dose-dependent bacteriocide effect on K. pneumoniae. For the cytosol examinations, the apparent values of Km and Vmax were 0.96+/-0.09 mM and 7.87+/-0.79 nmol min(-1) mg(-1) protein, respectively, for 2-AF. However, when DAS or DADS was added to the reaction mixtures, the apparent values of Km and Vmax were 0.16+/-0.04 mM and 0.99+/-0.16 nmol min(-1) mg(-1) protein with DAS, respectively, and 0.14+/-0.18 mM and 0.85+/-0.10 nmol min(-1) mg(-1) protein with DADS, respectively, for 2-AF. For the intact bacteria examination, the apparent values of Km and Vmax were 0.57+/-0.06 mM and 2.00+/-0.14 nmol min(-1) per 10x10(10) CFU, respectively, for 2-AF. However, when DAS or DADS was added to the reaction mixtures, the apparent of values of Km and Vmax were 0.41+/-0.04 mM and 1.30+/-0.10 nmol min(-1) per 10x10(10) CFU with DAS, respectively, and 0.34+/-0.04 mM and 1.08+/-0.08 nmol min(-1) per 10x10(10) CFU with DADS, respectively, for 2-AF. This report is the first demonstration to show that the garlic components DAS and DADS would affect K. pneumoniae growth and NAT activity.


Assuntos
Compostos Alílicos/farmacologia , Anticarcinógenos/farmacologia , Arilamina N-Acetiltransferase/metabolismo , Dissulfetos/farmacologia , Alho , Klebsiella pneumoniae/efeitos dos fármacos , Plantas Medicinais , Sulfetos/farmacologia , 2-Acetilaminofluoreno/metabolismo , Acetilação , Citosol/efeitos dos fármacos , Citosol/enzimologia , Relação Dose-Resposta a Droga , Alho/química , Humanos , Klebsiella pneumoniae/enzimologia , Klebsiella pneumoniae/crescimento & desenvolvimento
8.
Quintessence Int ; 27(8): 549-53, 1996 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9161258

RESUMO

The comfort on administration and effectiveness of electronic and local anesthesia for operative procedures, as perceived by clinicians and patients, were compared based on a 5-point Lickert scale, and a survey to solicit patient's feedback on the use of electronic anesthesia was conducted. Thirty patients, who required restorations on similar teeth bilaterally, and 10 clinicians were involved in the study. The two teeth in each patient were randomly restored under either electronic or local anesthesia. Administration of electronic anesthesia was perceived to be significantly more comfortable than that of local anesthesia, by both clinicians and patients. Local anesthesia was perceived to be significantly more effective by both evaluator groups, but 93.3% of the patients still preferred electronic anesthesia and would use it again. Minor after effects in some patients included redness of skin and briefly lingering sensation. All patients found electronic anesthesia easy to use, and most of the patients (93.3%) thought that the system was good to excellent.


Assuntos
Anestesia Dentária/métodos , Anestesia Local/métodos , Dor/prevenção & controle , Estimulação Elétrica Nervosa Transcutânea , Adulto , Preparo da Cavidade Dentária , Restauração Dentária Permanente , Humanos , Avaliação de Processos e Resultados em Cuidados de Saúde , Satisfação do Paciente , Estatísticas não Paramétricas , Inquéritos e Questionários
10.
IARC Sci Publ (1971) ; (20): 231-39, 1978.
Artigo em Inglês | MEDLINE | ID: mdl-569635

RESUMO

Twenty-four Chinese NPC patients under 25 years of age at the time of diagnosis were interviewed. The interviews were carried out in the presence of their families in 22 cases and concentrated on the environmental background of the subject's infancy and early childhood. An analysis of the results eliminated household inhalants, aerial contaminants, medicines, food therapy, spices, fresh foods and soya sauce as likely factors in carcinogenesis. The only remaining foods eaten by all subjects and worthy of consideration were laap cheung, salted fish and tau si. Salted fish was the most commonly eaten and the only one fed to babies. In childhood, the subjects had rarely or never been fed vegetables or fruits. Most had, since childhood, been characteristically sickly, inactive, withdrawn and choosy about their food. It would appear that consumption of salted fish and vitamin C-deficiency in early childhood are important environmental factors and that a certain personality type may be associated with an increased risk.


Assuntos
Carcinoma/etiologia , Meio Ambiente , Neoplasias Nasofaríngeas/etiologia , Adulto , Poluentes Atmosféricos , Animais , China/etnologia , Culinária , Dieta , Doença , Feminino , Peixes , Alimentos , Hong Kong , Humanos , Alimentos Infantis , Masculino , Carne , Personalidade , Fatores Socioeconômicos , Suínos , Chá , Verduras
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