RESUMO
Objective: To study the application of dexmedetomidine in pulmonary segment resection in lung cancer patients. Methods: A total of 120 patients with lung cancer who underwent segmentectomy in our hospital from January 2021 to January 2022 were selected and divided into a control group (60 cases) and a study group (60 cases) according to the lottery method. Early lung cancer was diagnosed by histopathology and imaging, which was in line with the indication of segmental pneumonectomy, and was not treated by radiotherapy, chemotherapy, and other means.Exclusion criteria: Patients with coagulation system diseases, middle and late-stage patients and distant metastasis were excluded. Before induction of anesthesia, the control group was injected with normal saline 0.6 µg/kg, and the study group was injected with dexmedetomidine 0.6 µg/kg. Before anesthesia induction (T0), ventilation for 0.5 h (T2), ventilation for 1 h (T2), and immediately after surgery (T3), the changes of hemodynamics, physiological stress, and internal environment stability indexes were analyzed, and adverse reactions and pulmonary symptoms were counted. Incidence of injury and cognitive impairment. Results: The comparison of the observation indicators at T0 time point of the two patient groups was insignificant (P > .05). The T1-T3 point had no significant fluctuation in the study group compared with the T0 point (P > .05). The T1-T3 point in the control group was significantly higher than the T0 point MAP, HR, PaO2, SOD, Cor decreased, PaCO2, MDA, ACTH increased, with obvious fluctuations (P < .05); T1 ~ T3, compared with the control group, the study group MAP, HR, PaO2, SOD, Cor increased, PaCO2, MDA, ACTH decreased (P < .05). There was no significant comparison of adverse reactions between the two groups (P > .05). Compared with the control group, lung injury and cognitive impairment incidence in the study group was lower (P < .05). Conclusion: Before anesthesia induction, intravenous injection of dexmedetomidine can maintain hemodynamic and internal environment stability in lung cancer patients, reduce stress damage to the body, and reduce the incidence of lung injury and cognitive impairment, with high application value. This will reduce the pain of patients in clinical.
RESUMO
Total flavones of Rhododendron simsii Planch flower (TFR) have a significant protective effect against cerebral ischemia-reperfusion injury. However, its mechanism is unclear. This study investigated the protection of TFR against cerebral ischemia-reperfusion injury via cystathionine-γ-lyase- (CSE-) produced H2S mechanism. CSE-/- mice and CSE-siRNA-transfected rat were used. Relaxation of cerebral basilar artery (CBA), H2S, and CSE mRNA were measured. TFR significantly inhibited cerebral ischemia-reperfusion-induced abnormal neurological symptom and cerebral infarct in the normal rats and the CSE+/+ mice, but not in the CSE-/- mice, and the inhibition was markedly attenuated in CSE-siRNA-transfected rat; TFR elicited a significant vasorelaxation in rat CBA, and the relaxation was markedly attenuated by removal of endothelium or CSE-siRNA transfection or coapplication of NO synthase inhibitor L-NAME and PGI2 synthase inhibitor Indo. CSE inhibitor PPG drastically inhibited TFR-evoked vasodilatation resistant to L-NAME and Indo in endothelium-intact rat CBA. TFR significantly increased CSE mRNA expression in rat CBA endothelial cells and H2S production in rat endothelium-intact CBA. The increase of H2S production resistant to L-NAME and Indo was abolished by PPG. Our data indicate that TFR has a protective effect against the cerebral ischemia-reperfusion injury via CSE-produced H2S and endothelial NO and/or PGI2 to relax the cerebral artery.