[Preliminary results of Chinese magnetic sphincter augmentation in treating gastroesophageal reflux disease].

Objective: To examine the preliminary clinical efficacy of Chinese magnetic sphincter augmentation (MSA) in the treatment of gastroesophageal reflux disease (GERD). Methods: According to the enrollment criteria for the MSA developed by ShengJieKang Co. and Shanghai Chest Hospital (SS-MSA) clinical trial, a total of 19 GERD patients were treated with SS-MSA from August 2018 to January 2020 at Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University. The majority of registered cases were male patients with age of (32.2±7.3) years (range: 22 to 50 years), height of (170.7±6.2) cm (range: 160 to 179 cm) and weight of (65.2±10.3) kg (range: 47.5 to 90.0 kg). SS-MSA was implanted via laparoscopy. The major evaluation indexs of postoperative efficacy were the total time of acid exposure within 24 hours and the total number of reflux. Secondary efficacy indicators included: (1) evaluation of the average daily dose of proton pump inhibitor medications; (2) the score of GERD health related quality of life questionnaire (GERD-Q) before and after MSA implantation. Paired design t-test was used to evaluate the efficacy of the SS-MSA. Results: A total of 19 patients underwent SS-MSA surgery successfully. The history of the GERD were 19 (54) months (M(Q(R))). The operation time was 63 (22) minutes and the in-hospital stay was 3 (2) days. No obvious surgical complications occurred. Postoperative adverse events included 14 cases with mild to moderate dysphagia exited after surgery, gradually eased within 1 to 3 months, 1 case with the removal of the device after 1 month of severe swallowing difficulties, 1 case of diarrhea. No corrosion, perforation, displacement occurred. The GERD-Q score (11.0(4.5) vs. 6(1.0), t=4.274, P=0.013), 24-hour acid exposure time (6.2(4.8)% vs. 0.1(0.9)%, t=5.814, P=0.004), and Demeester score (23.72(16.20) vs. 0.96(3.10), t=6.678, P=0.003) were significantly decreased 1 year after surgery(n=5). Proton pump inhibitor reuse rates were 6/18, 5/15, 3/10, and 1/5 in 1, 3, 6 and 12 months after the operation, respectively. Conclusions: SS-MSA implantation is feasible and safe with short hospital stay and rare perioperative complications. The preliminary results is good after 1 year follow-up. It could be expected to be an ideal substitutive for future GERD treatment.

[Contents analysis of zinc, manganese, copper and iron in 7 kinds of treatment gastritis Chinese traditional medicines].

The contents of Zn, Mn, Cu and Fe in 7 kinds of treatment gastritis Chinese traditional medicines are determined by FAAS. The results show that element Fe in medicines is very rich, but element Cu is lower. The relationship between trace elements and the factor that causes gastritis is discussed. It provides useful reference data for discussing the relations of trace elements and treatment of gastroenteritis.

[Analysis of the contents of Zn, Cu, Fe, Mn and Ni in suxiaoweiningchongji].

The contents of Zn, Cu, Fe, Mn and Ni in five groups of Suxiaoweiningchongii were determined by AAS. The results showed that he Fe content is the highest and Cu is the lowest, and the reduced order of contents from highest to lowest is Fe to Zn to Mn to Ni to Cu. The relationship between the trace elements in Suxiaoweiningchongji and the curative effect was discussed.

[Analysis of 4 metal elements in 11 kidney tonic Chinese traditional medicines].

The contents of Zn, Cd, K and Na in 11 kidney tonic Chinese traditional medicines usually used in clinical practice were determined by FAAS. The results showed that element Zn, which is closely related to yang deficiency of the kidney, and the macro elements K and Na, which are essential to human-body, are very rich, but element Cd is lower. The relations between trace elements and the therapeutic efficacy were discussed, and it is concluded that the results are in agreement with clinical usage of medicines by herbalists.