RESUMO
Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of recommendations about therapeutic aspects of HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype, based on the published scientific studies and guidelines, in a form that is reasonably comprehensible to patients and people without medical training. This final version was approved at the Hemochromatosis International meeting on 12th May 2017 in Los Angeles.
Assuntos
Hemocromatose , Feminino , Humanos , Masculino , Terapia por Quelação/métodos , Dieta , Hemocromatose/genética , Hemocromatose/terapia , Proteína da Hemocromatose/genética , Homozigoto , Flebotomia/métodosRESUMO
AIM: The aim of this study was to describe the complementary and alternative medicine methods most commonly used to alleviate symptom distress in persons with functional gastrointestinal disorders. BACKGROUND: People with functional gastrointestinal disorders face many challenges in their everyday lives, and each individual has his/her own way of dealing with this illness. The experience of illness often leads persons with functional gastrointestinal disorders to complementary and alternative medicine as a viable healthcare choice. DESIGN: Quantitative and describing design. METHOD: A study-specific complementary and alternative medicine questionnaire was used, including questions about complementary and alternative medicine methods used and the perceived effects of each method. Efficacy assessments for each method were preventive effect, partial symptom relief, total symptom relief or no effect. RESULTS: A total of 137 persons with functional gastrointestinal disorders answered the questionnaire, 62% (n = 85) women and 38% (n = 52) men. A total of 28 different complementary and alternative medicine methods were identified and grouped into four categories: nutritional, drug/biological, psychological activity and physical activity. All persons had tried at least one method, and most methods provided partial symptom relief. CONCLUSION: Persons with functional gastrointestinal disorders commonly use complementary and alternative medicine methods to alleviate symptoms. Nurses have a unique opportunity to expand their roles in this group of patients. RELEVANCE TO CLINICAL PRACTICE: Increased knowledge of complementary and alternative medicine practices would enable a more comprehensive patient assessment and a better plan for meaningful interventions that meet the needs of individual patients.
Assuntos
Terapias Complementares/métodos , Gastroenteropatias/diagnóstico , Gastroenteropatias/terapia , Estresse Psicológico/terapia , Dor Abdominal/epidemiologia , Dor Abdominal/terapia , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Distribuição de Qui-Quadrado , Estudos de Coortes , Terapias Complementares/estatística & dados numéricos , Constipação Intestinal/epidemiologia , Constipação Intestinal/terapia , Diarreia/epidemiologia , Diarreia/terapia , Feminino , Gastroenteropatias/prevenção & controle , Azia/epidemiologia , Azia/terapia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Náusea/epidemiologia , Náusea/terapia , Qualidade de Vida , Medição de Risco , Índice de Gravidade de Doença , Distribuição por Sexo , Inquéritos e Questionários , Resultado do Tratamento , Adulto JovemRESUMO
Dyspepsia is a common disorder. A lack of effective therapies for managing dyspepsia may invite use of complementary and alternative medicine (CAM). The aim of this study was to elucidate CAM methods and their perceived effects in a middle-sized community in Sweden. Group interviews were used. Persons with uninvestigated dyspepsia, according to the Rome II criteria, were included. Data were studied systematically using manifest content analysis. A total of 25 persons (13 women and 12 men) were assigned to five different groups. The CAM methods used by participants were categorized as follows: (1) nutritional, (2) drug/biological, (3) spiritual/psychological, and (4) physical activity. In this study, 26 CAM methods associated with various effects were identified and all persons had used at least one method.
Assuntos
Terapias Complementares/estatística & dados numéricos , Dispepsia/terapia , Automedicação/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Grupos Focais , Humanos , Masculino , Medicina Tradicional , Pessoa de Meia-Idade , Medicamentos sem Prescrição , Fitoterapia , SuéciaRESUMO
BACKGROUND/AIMS: The altered iron metabolism in hepatocellular carcinomas (HCCs), characterized by the iron-deficient phenotype, is suggested to be of importance for tumour growth. However, the underlying molecular mechanisms remain poorly understood. We asked whether these iron perturbations would involve altered expression of genes controlling iron homeostasis. METHODS: HCCs were induced in rats by the Solt and Farber protocol of chemical hepatocarcinogenesis, and to evaluate the effects of iron loading, one group of animals were supplemented with dietary iron during tumour progression. Tissue iron contents were determined, labelling indices of S-phase nuclei were calculated, and mRNA levels of iron-regulatory genes were quantitated. Protein levels of ferroportin1 were determined with Western blot. RESULTS: HCCs displayed reduced amount of tissue iron and lack of histologically stainable iron. HCCs expressed significantly higher mRNA levels of genes involved in iron uptake (transferrin receptor-1, divalent metal ion transporter-1), ferroxidase activity (Ferritin-H), and iron extrusion (ferroportin1). The protein levels of ferroportin1 in iron-deficient HCCs were similar as in control livers, and did not increase in HCCs exposed to iron. Hepcidin mRNA levels were decreased in iron-deficient HCCs, rose in response to iron loading and correlated to the tissue iron content. CONCLUSIONS: Taken together, the altered expressions of iron-regulatory genes in HCCs possibly reflect an increased demand for bioavailable iron and a high iron turnover in neoplastic cells.