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Mol Cell Biochem ; 173(1-2): 121-5, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9278262

RESUMO

The effect of thioacetamide-induced liver cirrhosis on plasma and tissue manganese levels and the protective role of selenium, zinc and allopurinol supplements was investigated in rats. Control plasma and liver manganese (Mn) levels were found to be (mean +/- SD): 8.4 +/- 2.4 mg/L and 5.7 +/- 1.5 mg/g wet weight respectively. Plasma manganese levels were significantly increased (p < 0.001) whereas liver manganese levels were significantly reduced (p < 0.05) in the cirrhotic rats. Treatment with selenium, zinc and allopurinol reversed this trend and restored the manganese levels close to the normal values. Lung, spleen, and kidney manganese levels under control conditions were considerably lower than that of the liver tissue. However, these levels registered a significant increase (p < 0.05) in cirrhotic rats and this change was normalized after selenium, zinc and allopurinol treatment. There were no significant differences in the comparative efficacy of each of these protective agents. Zinc supplement considerably increased the plasma zinc levels and plasma Zn/Mn ratio had a good correlation with plasma zinc concentration. This ratio was significantly reduced in cirrhotic rats, but returned to the control level after zinc, selenium and allopurinol treatment. The results of this study indicate that the trace element, manganese, plays an important role in stabilizing cell structure and that this effect is mediated possibly by preserving the antioxidant activity of the tissues.


Assuntos
Alopurinol/uso terapêutico , Suplementos Nutricionais , Cirrose Hepática Experimental/tratamento farmacológico , Manganês/sangue , Selênio/uso terapêutico , Zinco/uso terapêutico , Ração Animal , Animais , Rim/química , Rim/efeitos dos fármacos , Fígado/química , Fígado/efeitos dos fármacos , Cirrose Hepática Experimental/induzido quimicamente , Pulmão/química , Pulmão/efeitos dos fármacos , Masculino , Ratos , Ratos Wistar , Baço/química , Baço/efeitos dos fármacos , Tioacetamida , Distribuição Tecidual/efeitos dos fármacos , Zinco/sangue
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