RESUMO
OBJECTIVE: To study the penetration of mexidol through the blood-brain barrier into different brain compartments and cell mitochondria. MATERIAL AND METHODS: The study was carried out on adult male Wistar rats using the drug mexidol ("Farmasoft" Russia). The penetration of mexidol into different compartments of the brain (the cortex, cerebellum, thalamus and medulla) and distribution between mitochondrial and cytoplasmic fractions of the cerebral cortex was studied. The concentration of mexidol in blood plasma and brain tissues was measured using HPLC. RESULTS AND CONCLUSION: Mexidol penetrated through the blood-brain barrier into brain compartments of rats with the maximal accumulation in the cortex. In the brain cortex cells, mexidol was identified in the cytoplasmic and mitochondrial fractions.
Assuntos
Antioxidantes/farmacocinética , Barreira Hematoencefálica/metabolismo , Picolinas/farmacocinética , Animais , Cerebelo/metabolismo , Córtex Cerebral/metabolismo , Citosol/metabolismo , Masculino , Bulbo/metabolismo , Mitocôndrias/metabolismo , Ratos , Ratos Wistar , Tálamo/metabolismo , Distribuição TecidualRESUMO
Hippophae, Rosa and plantain oils have been shown to produce and essential therapeutic action on chemical burns of rabbit eye. The effect was attained in the phases of trophic disturbances and epithelialization.
Assuntos
Queimaduras Químicas/tratamento farmacológico , Queimaduras Oculares/tratamento farmacológico , Óleos de Plantas/uso terapêutico , Plantago , Plantas Medicinais , Animais , Lesões da Córnea , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Soluções Oftálmicas , Coelhos , Fatores de TempoAssuntos
Vasos Sanguíneos/metabolismo , Intoxicação por Tetracloreto de Carbono/metabolismo , Catecolaminas/metabolismo , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Eletrólitos/metabolismo , Equilíbrio Hidroeletrolítico/efeitos dos fármacos , Doença Aguda , Animais , Vasos Sanguíneos/efeitos dos fármacos , Intoxicação por Tetracloreto de Carbono/tratamento farmacológico , Gatos , Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Avaliação Pré-Clínica de Medicamentos , Silimarina/uso terapêutico , Fatores de TempoRESUMO
The effects of aevite and riboflavin on electrolyte balance in the vessel wall were studied in toxic hepatitis in the cat. Significant changes in the contents of Na+, K+, Ca2+ and Mg2+ ions in the hepatic blood vessels were found in all periods of observation. The treatment of toxic hepatitis with aevite and riboflavin results in normalization of electrolyte balance of the vessel wall.