RESUMO
BACKGROUND: Quality of life has become an important aspect in the measurement of the health of an individual as the population ages. Rhythm-centred music making (RMM) has been shown to improve physical, psychological and social health. The purpose of this study was to explore the effects of RMM on quality of life, depressive mood, sleep quality and social isolation in the elderly. METHODS: A randomised controlled trial with cross over was conducted. 54 participants were recruited with 27 participants in each arm. In phase 1, group A underwent the intervention with group B as the control. In phase 2, group B underwent the intervention with group A as the control. The intervention involved 10 weekly RMM sessions. Patient related outcome data which included European Quality of Life-5 Dimensions (EQ5D), Geriatric Depression Scale (GDS), Pittsburg Sleep Quality Index (PSQI) and Lubben Social Network Scale (LSNS) scores were collected before the intervention, at 11th and at the 22nd week. RESULTS: A total of 31 participants were analyzed at the end of the study. The mean age was 74.65 ± 6.40 years. In analysing the change in patient related outcome variables as a continuous measure, participation in RMM resulted in a non-significant reduction in EQ5D by 0.004 (95% CI: -0.097,0.105), GDS score by 0.479 (95% CI:-0.329,1.287), PSQI score by 0.929 (95% CI:- 0.523,2.381) and an improvement in LSNS by 1.125 (95% CI:-2.381,0.523). In binary analysis, participation in RMM resulted in a 37% (OR = 1.370, 95% CI: 0.355,5.290), 55.3% (OR = 1.553, 95% CI: 0.438,5.501), 124.1% (OR = 2.241, 95% CI = 0.677,7.419) and 14.5% (OR = 1.145, 95% CI = 0.331,3.963) non-significant increase in odds of improvement in EQ5D, GDS, PSQI and LSNS scores respectively. CONCLUSION: Participation in RMM did not show any statistically significant difference in the quality of life of the participants. It is however, an interesting alternative tool to use in the field of integrative medicine. Moving forward, a larger study could be performed to investigate the effects of RMM on the elderly with an inclusion of a qualitative component to evaluate effects of RMM that were not captured by quantitative indicators. TRIAL REGISTRATION: This trial was retrospectively registered. This trial was registered in the Australian New Zealand Clinical Trials Registry under trial number ACTRN12616001281482 on 12 September 2016.
Assuntos
Envelhecimento/psicologia , Musicoterapia , Afeto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Projetos Piloto , Qualidade de VidaRESUMO
Triterpenoids of ursane class: ursolic acid, ilelatifol D, corosolic acid and euscaphic acid were isolated for the first time from Leonurus cardiaca, a member of the family Lamiaceae. The isolated compounds were tested for their cell-based antiinflammatory potential by suppressing respiratory burst activity and superoxide scavenging property by using xanthine/xanthine oxidase system to produce superoxides in the cell-free system. Ursolic acid was found to be an excellent inhibitor for the superoxides produced in the cellular system, while the same was inactive in the superoxide scavenging activity in cell-free system.
Assuntos
Sequestradores de Radicais Livres/farmacologia , Explosão Respiratória/efeitos dos fármacos , Superóxidos/antagonistas & inibidores , Triterpenos/farmacologia , Células Cultivadas , Relação Dose-Resposta a Droga , Sequestradores de Radicais Livres/química , Humanos , Lamiaceae/química , Estrutura Molecular , Neutrófilos/citologia , Neutrófilos/efeitos dos fármacos , Neutrófilos/metabolismo , Superóxidos/metabolismo , Triterpenos/química , Xantina Oxidase/metabolismo , Ácido UrsólicoRESUMO
The methanolic extracts of Bougainvillea spectabilis (Nyctaginaceae) flowers (five different colors) were screened biologically by performing four bioassays: antibacterial, antifungal, brine shrimp lethality and phytotoxicity. It was observed that the methanolic extract of white flowers was the most biologically active among all tested extracts. The extracts of white, orange and shocking pink flowers inhibit, while the extracts of red and violet flowers promote, the growth of Lemna plants. The extract of white flowers also exhibits toxicity against shrimp larvae with a LD50 value of 33.5627 microg/mL. However, none of the tested samples gave positive responses against any tested fungi.
Assuntos
Nyctaginaceae , Fitoterapia , Extratos Vegetais/farmacologia , Animais , Antibacterianos/administração & dosagem , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Antifúngicos/administração & dosagem , Antifúngicos/farmacologia , Antifúngicos/uso terapêutico , Artemia/efeitos dos fármacos , Cor , Flores , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Humanos , Dose Letal Mediana , Testes de Sensibilidade Microbiana , Fungos Mitospóricos/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêuticoRESUMO
A new flavanone with epoxy-isopentyl moiety named parkintin has been isolated from the methanol soluble part of Parkinsonia aculeata Linn. belonging to the family Caesalpiniaceae. The structure of parkintin has been established with the aid of spectroscopic techniques including COSY and HMBC experiments.