La determinación peroperatoria de PTHi como factor predictivo de curación en el hiperparatiroidismo / Intraoperative intact parathyroid hormone determination as a predictive factor of hyperparathyroidism resolution

Introducción. Nuestros objetivos son valorar la eficacia de la determinación peroperatoria de la hormona paratiroidea intacta (PTHi) como marcador de curación del hiperparatiroidismo (HPT), establecer el número mínimo de muestras sanguíneas necesarias y comprobar si la manipulación cervical eleva la PTHi basal. Pacientes y método. Estudio prospectivo realizado con 45 pacientes. Peroperatoriamente se hicieron 3 determinaciones sanguíneas de PTHi: basal y a los 10 y 25 min de extirpar la lesión. Para analizar los efectos de la manipulación cervical, en 19 pacientes, se hicieron otras 2 determinaciones tras 2 min de masaje en ambos lados del cuello. Se aceptó como criterio diagnóstico y terapéutico el descenso > 50% del valor de PTHi entre las muestras postexeréticas y la basal (gradiente > 50) y como criterio de curación la normalización de la calcemia. Resultados. Siempre que se extirpó la causa del HPT hubo descensos de PTHi a los 10 y 25 min de la exéresis. Este descenso tuvo valor predictivo de curación cuando el gradiente fue > 50. La manipulación cervical (masaje) no produjo elevación de la cifra de PTHi. En los casos curados, también se normalizaron las cifras de la calcemia. Conclusiones. La determinación intraoperatoria de PTHi, con gradiente > 50, es un excelente indicador de curación. Sólo se precisan 2 muestras de PTHi: la basal y la extraída a los 10 min de la exéresis. La manipulación cervical preoperatoria no produjo elevación de los valores de PTHi (AU)

Introduction. The objectives of this study were: a) to evaluate the effectiveness of intraoperative intact parathyroid hormone (PTHi) determination as a marker of hyperparathyroidism resolution; b) to establish the minimum number of blood samples required; and c) to determine whether cervical manipulation increases baseline PTHi levels. Patients and method. We performed a prospective study in 45 patients. Three intraoperative blood PTHi determinations were performed: at baseline and at 10 and 25 minutes after excising the lesion. To analyze the effects of cervical manipulation, in 19 patients, 2 further determinations were made after 2 minutes of massage on both sides of the neck. A decrease of > 50% in PTHi values between postexeresis samples and the baseline sample (gradient > 50%) was used as diagnostic and therapeutic criteria and normalization of calcemia was used as a criteria for complete resolution. Results. Whenever the lesion causing hyperparathyroidism was extirpated, PTHi levels decreased at 10 and 25 minutes after exeresis. This decrease was predictive of complete resolution when the gradient was > 50. Cervical manipulation (massage) did not increase PTHi values. In patients with complete resolution, blood calcium levels also returned to normal. Conclusions. 1. Intraoperative PTHi determination with a gradient > 50 is an excellent prognostic marker of resolution. 2. Only 2 PTHi samples are required: one at baseline and another at 10 minutes after exeresis. 3. Preoperative cervical manipulation does not increase PTHi values (AU)

[Zinc deficiency caused by postgastrectomy fistula with high flow in a patient undergoing prolonged parenteral nutrition]. / Déficit de zinc debido a fístula posgastrectomía de alto débito en paciente sometido a nutrición parenteral prolongada.

A case is presented of a 57-year-old male patient who underwent total gastrectomy due to gastric adenocarcinoma. During the postoperative period the patient required long-term parenteral nutrition due to a high-debit GI fistula (over 700 ml/day) and sepsis. Two months after parenteral nutrition was started, the patients presented irritability, mucocutaneous lesions and progressive bolding. Serum alkaline phosphatase and zinc levels were lower than normal, although a supplemental 0.03 mg/k/day of zinc was administered. Faced with this zinc deficiency picture, 10 mg zinc sulfate was administered parenterally on a daily basis. The deficiency picture improved markedly over a week's period, and serum zinc and alkaline phosphatase levels returned to normal. The importance of zinc balance control in patients under long-term parenteral nutrition and high fluid debit through GI fistulas is highlighted.