RESUMO
Brain masses diagnosed in 47 pet dogs as tumors by CT scans, and confirmed in 12 dogs by necropsies, were injected with iodinated contrast media and treated by a modified CT scanner, the CTRx. Twenty-six dogs that received six or more weekly treatments of about 5.6 Gy per fraction, of which about 25% was contributed by radiation from the iodine, for a median total dose of 39 Gy, had a median survival of 230 days. This compares well with the 150 days reported for 25 dogs given 46-48 Gy of cobalt-60 radiation to the whole brain, and is significantly greater than the 6 to 13 days in untreated historic controls.
Assuntos
Astrocitoma/veterinária , Neoplasias Encefálicas/veterinária , Doenças do Cão/radioterapia , Neoplasias Meníngeas/veterinária , Meningioma/veterinária , Terapia por Raios X , Animais , Astrocitoma/mortalidade , Astrocitoma/radioterapia , Biópsia , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/radioterapia , Doenças do Cão/mortalidade , Cães , Neoplasias Meníngeas/mortalidade , Neoplasias Meníngeas/radioterapia , Meningioma/mortalidade , Meningioma/radioterapia , Tamanho do Órgão , Doses de Radiação , Distribuição Aleatória , Taxa de Sobrevida , Tomografia Computadorizada por Raios X/veterinária , Terapia por Raios X/veterináriaRESUMO
Linoleic acid (LA) administered orally as safflower oil (SFO), which is 76% LA, produced remission in 6 out of 8 dogs with mycosis fungoides (MF). Following each feeding of SFO on 5 successive days to a normal dog peak plasma levels of non-esterified (free) LA in excess of 200 microM were observed. No clinical toxicity was observed from the SFO feedings in the normal or MF animals at the levels of SFO (3 ml/kg) used in these studies. However, a marked rise in white blood cells (WBC) and lymphocytes and a marked transient drop in the serum glutamine transaminases SGOT and SGPT was noted both in the normal and MF animals. These effects of LA may be significant for the remission of MF.