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Métodos Terapêuticos e Terapias MTCI
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1.
Intern Med ; 58(10): 1507-1509, 2019 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-30713291

RESUMO

We herein report a teenage girl who had been taking oral contraceptive pills for three months and complained of left lower abdominal pain that had continued for two months. A physical examination indicated anterior cutaneous nerve entrapment syndrome (ACNES), although no abnormality was found in various biochemical and imaging examinations. The pain was only transiently ameliorated by trigger-point injection, and neurectomy surgery was eventually effective. Sex steroids can be involved in the progress of local tissue edema causing ACNES. ACNES should be considered in cases of abdominal pain in patients taking oral contraceptives.


Assuntos
Dor Abdominal/etiologia , Dor Abdominal/cirurgia , Anticoncepcionais Orais/efeitos adversos , Denervação/métodos , Síndromes de Compressão Nervosa/induzido quimicamente , Síndromes de Compressão Nervosa/cirurgia , Adolescente , Feminino , Humanos , Resultado do Tratamento
2.
World J Gastroenterol ; 23(33): 6155-6163, 2017 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-28970731

RESUMO

AIM: To identify the clinical features of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with extra copies of MALT1. METHODS: This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated. RESULTS: Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (P = 0.10). CONCLUSION: Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1.


Assuntos
Antibacterianos/uso terapêutico , Antineoplásicos/uso terapêutico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/efeitos dos fármacos , Linfoma de Zona Marginal Tipo Células B/terapia , Proteína de Translocação 1 do Linfoma de Tecido Linfoide Associado à Mucosa/genética , Neoplasias Gástricas/terapia , Idoso , Aneuploidia , Cromossomos Humanos Par 11/genética , Cromossomos Humanos Par 18/genética , Intervalo Livre de Doença , Feminino , Mucosa Gástrica/microbiologia , Mucosa Gástrica/patologia , Mucosa Gástrica/efeitos da radiação , Infecções por Helicobacter/microbiologia , Helicobacter pylori/isolamento & purificação , Humanos , Hibridização in Situ Fluorescente , Linfoma de Zona Marginal Tipo Células B/genética , Linfoma de Zona Marginal Tipo Células B/microbiologia , Linfoma de Zona Marginal Tipo Células B/mortalidade , Masculino , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/genética , Radioterapia/métodos , Estudos Retrospectivos , Fatores Sexuais , Neoplasias Gástricas/genética , Neoplasias Gástricas/microbiologia , Neoplasias Gástricas/mortalidade , Translocação Genética , Resultado do Tratamento
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