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1.
Artigo em Chinês | WPRIM | ID: wpr-318479

RESUMO

The response rules of pressing pain on the back section in the Governor Vessel in patients with gastro-esophageal reflux disease (GERD) were studied to provide references for the diagnosis and treatment of GERD. Seventy-six cases of GERD were included into an observation group while 30 healthy volunteers were recruited into a control group. A mechanical measurement device of pressing pain that could measure the pain threshold was adapted to observe the pressing pain on the back section in the Governor Vessel in GERD patients and healthy volunteers. The test area is from spinous process of the 1st thoracic vertebra to that of the 12th thoracic vertebra (T1 -T12), including acupoints and non-acupoints on the Governor Vessel. As a result, in the observation group the pain threshold of T5-T7 spinous process clearance, which was the location of Shendao (GV 11), Lingtai (GV 10) and Zhiyang (GV 9), was lower than that in the control group (all P < 0.05). This result indicated that there was significant pressing pain in T5-T7 spinous process clearance in patients with GERD, which could be taken as an important auxiliary diagnosis and a new thinking method in the treatment of GERD with acupuncture.


Assuntos
Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Diagnóstico Diferencial , Refluxo Gastroesofágico , Diagnóstico , Meridianos , Pressão , Sensação , Vértebras Torácicas
2.
Artigo em Chinês | WPRIM | ID: wpr-316026

RESUMO

<p><b>OBJECTIVE</b>To observe the effects of Xuezhikang and simvastatin on cerebral ischemia/reperfusion injury in rat, as well as the influences after intervention with L-NAME.</p><p><b>METHOD</b>Rats were given orally with Xuezhikang and simvastatin or vehicle for 2 weeks, and then subjected to middle cerebral artery occlusion for 120 min using intraluminal filament model. L-NAME were injected into the lateral ventricles in half of the rats treated with Xuezhikang and simvastatin 45 min before the ischemia. The neurological deficits examinations were performed at 2, 24, 48 h after reperfusion. After the last examination the animals were sacrificed, the infarct volumes were determined by TTC staining, and MDA levels were also measured.</p><p><b>RESULT</b>Xuezhikang and simvastatin both significantly reduced the infarct volume and improved the functional recovery when compared to vehicle. Xuezhikang and simvastatin both significantly decreased the MDA accumulation after reperfusion. L-NAME partially inhibited the protective effect of Xuezhikang but nearly completely abolished the protective effect of simvastatin.</p><p><b>CONCLUSION</b>Xuezhikang has protective effects on ischemic brain damage in rats, which the beneficial effects are partly due to the statins components. The other components in Xuezhikang may also account for the neuroprotective effects, which is worth further investigations.</p>


Assuntos
Animais , Masculino , Ratos , Encéfalo , Patologia , Isquemia Encefálica , Metabolismo , Patologia , Medicamentos de Ervas Chinesas , Farmacologia , Infarto da Artéria Cerebral Média , Malondialdeído , Metabolismo , NG-Nitroarginina Metil Éster , Farmacologia , Fármacos Neuroprotetores , Farmacologia , Ratos Sprague-Dawley , Traumatismo por Reperfusão , Metabolismo , Patologia , Sinvastatina , Farmacologia
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