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Métodos Terapêuticos e Terapias MTCI
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Int J Biol Macromol ; 139: 605-613, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31381909

RESUMO

Coix (Coix lachryma-jobi L.), commonly known as adlay, is a traditional Chinese medicine for thousands of years. A new water-soluble polysaccharide with anti-diabetic activity was extracted and purified from the adlay seed (PAS). The structure and physicochemical properties of PAS were determined by Fourier transform infrared spectrometer (FT-IR) and scanning electron microscopy (SEM). Structural analysis indicated that PAS had a porous surface and relatively loose distribution. After intragastric administered PAS for 4 weeks, biochemical analysis demonstrated dose dependent anti-diabetic activity. These results showed that PAS decreased blood glucose and insulin levels. In addition, mice fed the PAS showed significantly reduced the plasma levels of amyloid ß42 and glycated hemoglobin (HbA1c), while the expression of glucagon-like peptide-1 (GLP-1) was markedly increased. Our study introduced a new polysaccharide PAS with unique anti-diabetic activity, which can be used as a potential dietary supplement or functional food.


Assuntos
Coix/química , Hipoglicemiantes/farmacologia , Polissacarídeos/química , Sementes/química , Peptídeos beta-Amiloides/metabolismo , Animais , Glicemia/análise , Peso Corporal , Peptídeo 1 Semelhante ao Glucagon/metabolismo , Teste de Tolerância a Glucose , Hemoglobinas Glicadas/metabolismo , Insulina/metabolismo , Rim/enzimologia , Fígado/enzimologia , Masculino , Medicina Tradicional Chinesa , Camundongos , Camundongos Endogâmicos ICR , Microscopia Eletrônica de Varredura , Fragmentos de Peptídeos/metabolismo , Extratos Vegetais/química , Porosidade , Dobramento de Proteína , Espectroscopia de Infravermelho com Transformada de Fourier , Superóxido Dismutase/metabolismo
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