1.
Chem Biodivers
; 18(12): e2100499, 2021 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34761862
RESUMO
A new natural Diels-Alder adduct (3) was isolated from the leaves and stem bark of Artocarpus integer, along with seventeen known compounds (1, 2, and 4-18). Structural elucidation was conducted using NMR and HR-ESI-MS data, and comparisons were made with previous studies. Deoxyartoninâ I (3) exhibited the most potent α-glucosidase inhibition (IC50 7.80±0.1â µM), outperforming the acarbose positive control. This was mixed-mode inhibition, as indicated by the intersect in the second quadrant of each respective plot. An inâ silico molecular docking model and the pharmacokinetic features of 3 suggest that it is a potential inhibitor of enzyme α-glucosidase, and is therefore a lead candidate as a drug against diabetes mellitus.