[Changes in the cerebellar cortex of rabbits subjected to an electrical current on the posterior hypothalamus]. / Izmeneniia kory polusharii mozzhechka krolika pri deistvii élektricheskogo toka na zadnee pole gipotalamusa.

After 3, 15 and 30 sessions of electrical stimulation of the hypothalamus by means of stereotaxically implanted bipolar electrodes into the area hypothalamica posterior, in the cortex of the cerebellar hemispheres, predominantly in the ganglionic layer, certain reactive, as well as poorly and intensively manifested pathological changes develop in neural and glial cells. Mosaicism of Purkinje's cells lesions within the layer, the state of their cytoplasmic matrix, granular endoplasmic reticulum and mitochondria, essential shifts in activity of oxidation-reduction enzymes at a simultaneous disorder in blood circulation and decreased content of catecholamines in the neural structures of the cerebellar vessels make it possible to estimate the process as centrogenic and neurodistrophic.

[Structural and metabolic changes in the limbic cortex of the rabbit in response to experimentation with the hypothalamus]. / Strukturnye i metabolicheskie izmeneniia v limbicheskoi kore krolika pri vozdeistvii na gipotalamus.

By means of the light and electron microscopy, histochemical and cytophotometrical methods the anterior subarea of the cerebral limbic cortex has been studied in 30 experimental and 30 control rabbits. The experimental animals have been given 3, 15 and 30 sessions (1 h per day) of electric irritation (0.05 mA, 50 Hz, 1 msec) on the posterior hypothalamic field (PHF). Twelve rabbits from 30 control animals make an intact group and 18--a group with inactive electrodes inserted into the PHF. After 3 and especially after 15 sessions it has been revealed: in neurons--an acute swelling, edematous alterations, hyperchromatosis and shrinkage, changes in lactate dehydrogenase, succinic dehydrogenase, nicotinamide-adenine-dinucleotide-diaphorase and nicotinamide-adenine-dinucleotide-phosphate-diaphorase activities, in neuroglia--hypertrophy and weakly manifested hyperplasia. After 30 sessions synapses degenerated after the dark type are revealed. More intensive structural and metabolic changes are noted in the middle cytoarchitectonical complex. The changes of the enzymatic activity are considered as certain signs of weakening mitochondrial processes, connected with energy production, increasing glycolysis, decreasing level of the energetic provision of the cytoplasmic synthesis, arising under conditions of a disturbed transneuronal influence on the cortex by the hypothalamus.