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Nat Commun ; 9(1): 3928, 2018 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-30279409

RESUMO

The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both scarce on the African continent and present a number of drawbacks as they are derived from the plasma of hyper-immunized large mammals. Here, we describe the development of an experimental recombinant antivenom by a combined toxicovenomics and phage display approach. The recombinant antivenom is based on a cocktail of fully human immunoglobulin G (IgG) monoclonal antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba whole venom in a rodent model. Our results show the potential use of fully human monoclonal IgGs against animal toxins and the first use of oligoclonal human IgG mixtures against experimental snakebite envenoming.


Assuntos
Anticorpos Monoclonais Humanizados/química , Antivenenos/química , Dendroaspis , Venenos Elapídicos/imunologia , Fatores Imunológicos/química , Mordeduras de Serpentes/tratamento farmacológico , Animais , Anticorpos Monoclonais Humanizados/uso terapêutico , Antivenenos/uso terapêutico , Avaliação Pré-Clínica de Medicamentos , Venenos Elapídicos/antagonistas & inibidores , Fatores Imunológicos/uso terapêutico , Camundongos , Testes de Neutralização
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