RESUMO
The pharmacokinetics of the new benzimidazole proton pump inhibitor lansoprazole and five of its metabolites were assessed after single oral dose administration to five hemodialysis patients. Patients were studied on dialysis and nondialysis days. Multiple blood and dialysate samples were collected after dosing and were assayed for lansoprazole and metabolite content via high-performance liquid chromatography. The degree of lansoprazole plasma protein binding was lower in hemodialysis patients than in subjects with normal renal function or patients with renal impairment not requiring dialytic therapy, although this tended to moderate when assessed immediately after dialysis. Examination of venous plasma concentration, paired arterial-venous concentration, and dialysate data revealed that lansoprazole and its metabolites were poorly dialyzable. No dosage adjustment of lansoprazole is necessary in hemodialysis patients nor is supplementation after hemodialysis sessions necessary.
Assuntos
Antiulcerosos/farmacocinética , Omeprazol/análogos & derivados , Inibidores da Bomba de Prótons , Diálise Renal , 2-Piridinilmetilsulfinilbenzimidazóis , Administração Oral , Adulto , Antiulcerosos/administração & dosagem , Antiulcerosos/sangue , Cromatografia Líquida de Alta Pressão , Soluções para Diálise/análise , Esquema de Medicação , ATPase Trocadora de Hidrogênio-Potássio/sangue , Humanos , Lansoprazol , Masculino , Pessoa de Meia-Idade , Omeprazol/administração & dosagem , Omeprazol/sangue , Omeprazol/farmacocinética , Ligação ProteicaRESUMO
A case demonstrating suspected teratogenic effects of topical podophylium is presented. Podophyllum resin was applied five times for a duration of 4 hr from the 23rd to the 29th week of pregnancy. At birth a simian crease on the left hand and a preauricular skin tag were noted. It is suggested that podophyllum be avoided during pregnancy. Alternative treatment for warts of the vaginal, perineal, or anal area are presented.