Effects of Fluorencarbonic Acid Derivative on the Levels of Monoamines and Their Metabolites in Brain Structures of Rats with Modeled Depression-Like State.

The effects of the new structural analogue of benactyzine, a derivative of fluorencarbonic acid, on monoamine levels in brain structures were studied in male Wistar rats with experimental depression. Depressive state in rats was modeled by single injection of reserpine (4 mg/kg). The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus and striatum were measured by HPLC. It was found that preliminary treatment (30 days) with the derivative of fluorencarbonic acid prevented a decrease in monoamine level in the hypothalamus (NE, 5-HT, and 5-HIAA) and striatum (DA, 5-HT, and 5-HIAA). The neurochemical shifts (correction of 5-HT deficiency and stabilization of DA and NE levels) correlated with the high antidepressant activity of this agent observed in Porsolt forced swimming test.

Behavioral, hormonal, and neurotransmitter reactions to stress in adult rats with a history of high IL-1ß content in the early postnatal ontogeny.

Behavioral, hormonal, and neurotransmitter reactions to foot shock were studied in adult rats treated with IL-1ß during week 3 of life. After stress, these animals differed from controls treated with saline by high levels of dopamine, serotonin, and 5-hydroxy-indolacetic acid in the hypothalamus. In contrast to controls, they developed a significant stress-induced increase of blood corticosterone level and exhibited lesser motor and exploratory activities in the open field test.

[Metabolic shifts in stress caused by hunger, and pharmacotherapy of them by a new taurine derivative]. / Metabolicheskie sdvigi pri stresse, vyzvannom golodaniem, i ikh farmakoterapiia novym proizvodnym taurina.

The influence of a new N-phenylalkyl derivative of taurine in combination with a diet enriched with soybean proteins was studied in rats with nutritional dystrophia induced by 3/4 reduced standard diet. It is shown biochemically and morphologically that usage of the drug simultaneously with the diet stimulated protein synthesis, reduced lipid peroxidation, normalized spermatogenesis and compensatory adaptation of different functions.

[The effect of neurotropic agents on lipid peroxidation in the heart and stomach with neurogenic lesions]. / Vliianie nekotorykh neirotropnykh sredstv na perekisnoe okislenie lipidov v serdtse i zheludke pri ikh neirogennom povrezhdenii.

Neurogenic gastric lesions in rats were induced by a combination of immobilization and 3-hour electrostimulation. Neurogenic cardiac injury in rabbits were induced by 3-hour electrical stimulation of the aortic arch. Thereafter the activation of lipid peroxidation in the stomach and heart was recorded. There was an increase in MDA levels and a decrease in antioxidative enzyme activity in the tissues and serum (catalase and superoxide dismutase). The administration of the neurotropic drugs which restore the activity of the sympathetic nervous system (L-DOPA, aethimizol, fenibut and piracetam) was shown to normalize the processes of lipid peroxidation.

[The effect of GABA-ergic agents on the development of a neurogenic stomach lesion in rats]. / Vliianie GAMK-ergicheskikh sredstv na razvitie neirogennogo povrezhdeniia zheludka krys.

Neurogenic gastric lesions in rats were induced by combination of immobilization with 3-h long electrostimulation. After this stress a distinct decrease of noradrenalin and creatine phosphate content and then the activation of lipid peroxidation (LPO) in the stomach tissue was recorded. If the stress treatment was preceded by application of piracetam and fenibute, gastric tissue trophic was protected by way of prevention from a decrease of the content of noradrenalin, creatine phosphate and the activation of LPO.

[A pharmacological analysis of the central monoaminergic mechanisms of the development of neurogenic stomach damage]. / Farmakologicheskii analiz tsentral'nykh monoaminergicheskikh mekhanizmov razvitiia neirogennogo povrezhdeniia zheludka.

It was found that 3 hours after electrostimulation of the immobilized rats there was observed in addition to destructive lesions in the gastric mucosa a significant decrease of noradrenaline, dopamine, DOPA, homovanillic acid and creatine phosphate levels in the brain tissue involving the hypothalamus and the midbrain surrounding it. The use before the extreme impact of neurotropic agents blocking transmission of the damaging impulses from the site of stimulation of reflexogenic zones through the central adrenergic synapses which activate genome in the nerve cell or prevent depletion of catecholamine stores and disturbance of energy formation processes in the brain tissue protects against the development of neurogenic damage of the stomach.

[Participation of hypothalamic adrenergic and cholinergic systems in the regulation of pituitary adrenocorticotropic function]. / Uchastie kholinergicheskikh i adrenergicheskikh sistem gipotalamusa v reguliatsii adrenokortikotropnoi funktsii gipofiza.

Experiments were conducted on male rats; a study was made of the activity of pituitary-adrenal cortex system under conditions of electrolyte destruction of various hypothalamic areas. Pharmacological analysis pointed to the irregular distribution in the hypothalamus of the cholinergic and adrenergic systems controlling the secretion of ACTH-glucocorticoids. As suggested, the cholinergic systems are situated in the mammillary region, alpha-adrenergic ones--in the anterior or the posterior regions of the hypothalamus, and beta-adrenergic receptors--in the ventromedial nuclei of the hypothalamus. The latter possibly play an inhibitory role.