RESUMO
New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
Assuntos
Adjuvantes Imunológicos/síntese química , Adjuvantes Imunológicos/farmacologia , Glicopeptídeos/química , Ácido Glicirrízico/síntese química , Ácido Glicirrízico/farmacologia , Adjuvantes Imunológicos/química , Animais , Éteres/química , Ácido Glicirrízico/química , CamundongosRESUMO
New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu(t) dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-type hypersensitivity in mice at a dose of 2 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
Assuntos
Adjuvantes Imunológicos/síntese química , Cisteína/química , Glicopeptídeos/síntese química , Ácido Glicirrízico/química , Adjuvantes Imunológicos/química , Adjuvantes Imunológicos/farmacologia , Glicopeptídeos/química , Glicopeptídeos/farmacologia , Ressonância Magnética Nuclear BiomolecularRESUMO
A phytopreparation from lucerne (Medicago sativa) was studied with respect to the acute and chronic toxicity and the action upon the cellular genetic mechanism. It was found that the preparation belongs to the group of practically nontoxic properties.
Assuntos
Medicago sativa/toxicidade , Animais , Células Cultivadas , Cães , Relação Dose-Resposta a Droga , Fígado/efeitos dos fármacos , Fígado/metabolismo , Fígado/patologia , Camundongos , Testes de Mutagenicidade/estatística & dados numéricos , Pomadas , Extratos Vegetais/toxicidade , Coelhos , Ratos , Testes Cutâneos/estatística & dados numéricos , Soluções , Comprimidos , Teratogênicos/toxicidade , Fatores de TempoRESUMO
The effect of eracond on some parameters of immunity and allergic reactions was studied in experiments on mice and guinea pigs. The drug was found to possess an immunomodulating effect.
Assuntos
Adjuvantes Imunológicos/farmacologia , Medicago sativa/química , Animais , Formação de Anticorpos/efeitos dos fármacos , Relação Dose-Resposta a Droga , Cobaias , Imunidade Celular/efeitos dos fármacos , Imunização , Masculino , Camundongos , Camundongos Endogâmicos CBA , Anafilaxia Cutânea Passiva/efeitos dos fármacos , Extratos Vegetais/farmacologiaRESUMO
The experiments on rats with toxic hepatic damage induced by tetrachloromethane have shown that the derivatives of glycyrrhizinic acid (5NGA) promote a decrease in the rate of lipid peroxide oxygenation in the hepatic tissue homogenate and the blood serum, in the inhibition of organospecific enzyme activity (BHMT, ALT, AST) and increase in choleresis. The data obtained testify to the hepatoprotective activity of the derivatives of glycyrrhizinic acid.