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Medicinas Complementares
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Biomed Pharmacother ; 117: 109066, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31226639

RESUMO

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Korean red ginseng is a Korean traditional medicine. In this study, we estimated the effects of Korean red ginseng water extract (RGE) in the 1-chloro-2,4-dinitrobenzene (DNCB)-induced BALB/c mouse model which develops AD-like lesions. After RGE administration (100, 200, and 400 mg/kg) to DNCB-induced mice there were improvements in the dermatitis score and skin pH, a decrease in trans-epidermal water loss, and improved skin hydration. RGE also significantly inhibited eosinophil infiltration, increased filaggrin protein levels, and decreased serum IgE levels, epidermal thickness, mast cell infiltration, and ceramidase release. Compared with that in DNCB-induced mice, RGE effectively decreased the mRNA expression levels of interleukin-6 (IL-6), thymic stromal lymphopoietin (TSLP), and tumor necrosis factor-α (TNF-α), as well as the protein level of thymus and activation-regulated chemokine (TARC). These inhibitory RGE effects are mediated by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. Furthermore, we confirmed that RGE suppresses interferon-γ (IFN-γ) and TNF-α-induced expression of macrophage-derived chemokine (MDC) and TARC genes in human keratinocyte (HaCaT) cells. Taken together, these results demonstrate that RGE may exert anti-atopic related to responses by suppression the expression of inflammatory mediators, cytokines, and chemokines via downregulation of MAPK signaling pathways, suggesting that RGE may be an effective therapeutic approach for prevention of AD-like disease.


Assuntos
Dermatite Atópica/tratamento farmacológico , Dermatite Atópica/enzimologia , Inflamação/tratamento farmacológico , Sistema de Sinalização das MAP Quinases , Panax/química , Extratos Vegetais/uso terapêutico , Água/química , Animais , Sobrevivência Celular/efeitos dos fármacos , Quimiocinas/metabolismo , Dermatite Atópica/patologia , Dinitroclorobenzeno , Modelos Animais de Doenças , Proteínas Filagrinas , Humanos , Inflamação/patologia , Mediadores da Inflamação/metabolismo , Queratinócitos/efeitos dos fármacos , Queratinócitos/metabolismo , Queratinócitos/patologia , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Masculino , Camundongos Endogâmicos BALB C , Fosforilação/efeitos dos fármacos , Extratos Vegetais/farmacologia , Pele/efeitos dos fármacos , Pele/patologia , Perda Insensível de Água/efeitos dos fármacos
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