1.
Clin Infect Dis
; 74(5): 905-908, 2022 03 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34079986
RESUMO
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.