1.
Med J Aust
; 155(3): 206, 1991 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1875822
2.
J Neurol Sci
; 84(2-3): 295-9, 1988 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2837542
RESUMO
The effects of 4 proteolytic enzymes, alpha-chymotrypsin, bromeline, collagenase, and lysozyme on amyloid tissue sections from a patient with familial amyloidotic polyneuropathy (FAP) were evaluated. Degradation of amyloid fibrils was significant with alpha-chymotrypsin, moderate with bromeline and collagenase, and slight with lysozyme. All of these proteases except collagenase are used as oral mucolytics in humans. The possibility of their clinical usefulness in the treatment or prevention of the development of FAP is discussed.