[The ultrastructural manifestations of the regenerative processes in the Sertoli cells under the action of low-intensity electromagnetic radiation in the rats subjected to stress].

The experiments on the outbred female rats using the electron microscopic technique have demonstrated that the application of ultrahigh frequency low-intensity electromagnetic radiation (LIEMR) with a flux density below 1 mCW/Cm2 and a frequency of approximately 1,000 MHz in the regime of primary prophylaxis and therapeutic-preventive action suppressed the development of the post-stress pathological ultrastructural changes and increased the activity of the regenerative processes in the Sertoli cells. It was shown that the developing adaptive and compensatory changes in the Sertoli cells most frequently involve the energy-producing structures (mitochondria) that undergo the enlargement of their average and total dimensions. Simultaneously, the amount of granular endoplasmic reticulum and the number of ribosomes increased while the intracellular links between the organelles strengthened and the reserve potential of the cells improved. It is concluded that the observed effects may be due to the action of both local and systemic regulation mechanisms.

[The regeneration process in the Sertoli cells and Leydig cells of the rats undergoing the combined treatment with drinking mineral water and a magnetic field under stressful conditions].

The experiments carried out on outbred white male rats have demonstrated that twice repeated immobilization stress resulted in the destruction of intracellular organelles and interfered with the regeneration processes in the Sertoli cells and Leydig cells. The combination of the consumption of drinking mineral sulfate water (MW) with the application of a constant or alternating magnetic field (MF) caused stimulation of intracellular regenerative reactions that were especially pronounced in the Sertoli cells in the form of enhanced organoid and intra-organoid regeneration of mitochondria. This in turn increased biological potential of the cells and thereby provided a basis for the further development of biosynthetic processes. The results of the study expose to a certain degree the causes and mechanisms responsible for the higher effectiveness of the combined action of mineral water and magnetic fields compared with the monofactor treatment (mineral water alone).

[Ultrastructural changes of sertoli cells in rat testicles treated with drinking mineral water in combination with microelements, zinc and silicon, under stress conditions].

The present experiments carried out on outbred male rats have demonstrated that the treatment with drinking mineral water in combination with microelements, zinc and silicon, significantly increased resistance of their cultured Sertoli cells to the stressful impact of a single immobilization event and promoted the development of intracelular adaptive and protective reactions. This response was manifest as a decrease in the level of the destructive processes and an enhancement of regenerative/hyperplastic reactions of mitochondria, ribosomes, and other intracellular organelles. Similar experiments with the use of sulfate mineral water revealed its less pronounced effect.

[Prevention of early post-stress disorders in rat testicles under effect of drinking sulfate mineral water containing zinc and silicium].

Experiments performed on outbred male rats have demonstrated that consumption of drinking sulfate mineral water containing microelements (zinc and silicium) considerably slows down the development of stress-induced pathological changes in the testicles compared with the action of pure mineral water containing no admixtures. This finding confirms the important role of zinc and silicon in combination with the ion-salt base of mineral water in the enhancement of the efficacy of the adaptive and protective reactions in the testicles during the early post-stress period.

[The use of drinking sulfate mineral water in combination with laser and magnetic-laser irradiation for primary prophylaxis of post-radiation disorders(experimental study)].

Experiments on laboratory rats have demonstrated that prophylactic use of drinkable sulfate mineral water in combination with laser and magnetolaser irradiation of adrenal glands produces a radioprotecive effect that was especially well apparent in the liver and less so in the testes. Simultaneously, the functional activity of the thymus decreased. Protection of the liver by the combination of the above factors was more pronounced than the effect of each of them applied separately.

[Hypothalamic ultrastructure in prophylactic use of mineral water for drinking in exposure to radiation]. / Ul'trastruktura gipotalamusa pri profilakticheskom primenenii pit'evykh mineral'nykh vod v usloviiakh radiatsionnogo oblucheniia.

Male rat experiments have established that preventive intake of mineral water before exposure to radiation prevents or decreases significantly ultrastructural alterations in paraventricular hypothalamic nucleus.

[The correction of the subcellular postradiation changes in the hypothalamus and parathyroid gland by using low-intensity laser radiation (an experimental study)]. / Korrektsiia subkletochnykh postradiatsionnykh izmenenii v gipotalamuse i parashchitovidnoi zheleze pri ispol'zovanii nizkointensivnogo lazernogo izlucheniia (éksperimental'noe issledovanie).

The exposure of the rat adrenals 30 days after radiation (1 Gy) to low-intensity infrared laser radiation arrests development of ultrastructural disorders in the cells of hypothalamus and parathyroid gland, enhances subcellular manifestations of adaptation and rehabilitation processes.

[Spermatogenesis in rats given potable sulfated mineral water in the early postradiation period]. / Sostoianie spermatogeneza u krys pri primenenii pit'evoi sul'fatnoi mineral'noi vody v rannem postradiatsionnom periode.

Rat experiments have shown that course intake (21 days) of sulphate sodium-magnesium-calcium water with sulphate concentration 2.6 mg/l and mineralization 3.1 g/l in early postradiation period (1-2 Gy) inhibits development of dystrophic and destructive processes in spermatogenic epithelium of the testes and maintains spermatogenesis at higher level than control.

[The action of potable mineral waters on reparative regeneration processes in the stomach]. / Deistvie pit'evykh mineral'nykh vod na protsessy reparativnoi regeneratsii v zheludke.

The analysis of the data obtained on effects of different drinking mineral waters on healing of experimental gastric ulcer has established different effects of the waters on the repair depending on chemical composition of the waters.

[The dependence of the radioprotective effect of iodine-containing waters on the concentration and form of the iodine]. / Zavisimost' radiozashchitnogo éffekta iodsoderzhashchikh vod ot kontsentratsii i formy ioda.

Preradiation intragastric injection of iodine-containing waters during 21 days increased mean survival and decreased the mortality of rats exposed to gamma-radiation (whole-body dose 5.4 and 6.4 Gy, dose rate 1.053 Gy/min). The highest radioprotective effect was reached in use of waters containing 49 and 100 mg/1 positive iodine ions in radiation dose 5.4 Gy. In the whole-body radiation 6.4 Gy, intragastric injection of water with 49 mg/1 positive ions resulted in 100% survival.

[The action of sulfate mineral water in experimental whole-body irradiation]. / Deistvie sul'fatnoi mineral'noi vody pri obshchem radiatsionnom obluchenii v éksperimente.

The authors' experiments have shown that a course intake of sulfate mineral water after total radiation (1 and 5 Gy) can prevent and minimize dystrophic and necrobiotic changes in the liver, stimulate intracellular regeneration, reduce pathological mitoses in the small intestine. The response depended on radiation dose and time of crenotherapy start after radiation. Sulfate mineral water is also a weak radioprotector.

[The ultrastructural aspects of the stress-limiting action of a pulsed electrical current on the hypothalamic neuronal subpopulations that initiate the body's stress reactions]. / Ul'trastrukturnye aspeky stress-limitiruiushchego deistviia impul'snogo élektricheskogo toka na subpopuliatsii neironov gipotalamusa, initsiiruiushchikh stressornye reaktsii organizma.

Electron-microscopic investigations of neuron subpopulations in paraventricular nuclei of rat hypothalamus demonstrated ultrastructural positive changes due to exposure of the stressed animals to impulse electric current (IEC). The latter is able to control synthesis and secretion of stress-releasing-hormones produced by neurons of hypothalamic medial small-cell and posterior large-cell subnuclei. There were indications of deposition of stress-initiating hormones in neuron bodies evidencing stress-limiting effect of IEC. There were also signs of elevated resistance of ultrastructures, endoplasmic reticulum, in particular, to stress-related damage.

[The postradiation restoration of the liver by using potable mineral waters]. / Postradiatsionnoe vosstanovlenie pecheni pri primenenii pit'evykh mineral'nykh vod.

In experiments with 135 white breed-less male rats it was shown that the drinking mineral waters containing sulphate or silic ions promoted the postradiated rehabilitation in the liver after whole-body 5 Gy gamma-ray exposure. The decrease of the rate of lipid peroxidation in hepatocyte membranes, the increase of quantity normal cells and the decrease of quantity dystrophic and necrobiotic cells, the change of haemostasis took place. The iodine- and boron-containing mineral waters were less efficacious in these processes than the waters with sulphate and silic ions.

[Postradiation recovery processes in the body with the internal use of iodine-containing waters]. / Postradiatsionnye vosstanovitel'nye protsessy v organizme pri vnutrennem primeneniem iodsoderzhashchikh vod.

It is shown that both natural and dissolved iodine-bromine water given in courses to animals preexposed to 1 Gy gamma radiation promotes recovery of the damaged processes in the body. The therapeutic action of natural mineral water proved more beneficial because such water contains more iodine and minerals.