Acute exacerbation of idiopathic pulmonary fibrosis treated using the Feibi recipe: Two case reports.

BACKGROUND: Rationale: No other treatment besides lung transplant is effective for idiopathic pulmonary fibrosis (IPF). Patients with IPF have poor prognosis, which may eventually lead to death. Patient concerns: Two female patients were diagnosed with IPF. In our recent follow-up, both these patients maintained a good quality of life. CASE SUMMARY: Diagnosis: Both patients had dry cough and progressive dyspnea. Interventions: The first patient was treated with prednisone, and the second patient was treated with prednisone and tripterygium glycosides. However, the symptoms did not improve and fibrosis was not controlled. Thus, the Feibi recipe was used. Outcomes: No deterioration was observed after the treatment, and the dry cough and its effect were ameliorated. Furthermore, they are still alive and the quality of their lives has improved. CONCLUSION: These two cases suggest that the Feibi recipe and other traditional Chinese medicine therapies could be beneficial for IPF treatment.

Quantifying the effects of Robinia pseudoacacia afforestation on plant community structure from a functional perspective: New prospects for management practices on the hilly and gullied Loess Plateau, China.

Robinia pseudoacacia is regarded as a valuable but problematic plant due to its positive and negative environmental effects. A comprehensive and mechanistic understanding of the effects of R. pseudoacacia afforestation on ecosystems and striking a balance between ecosystem safety and functioning and R. pseudoacacia naturalization are crucially important. To achieve these goals, studying the community functional structure of R. pseudoacacia plantations is an essential prerequisite that remains understudied. Through quantifying and comparing the functional structure of R. pseudoacacia plantations and naturally restored communities relating to soil erosion control and plant ecology strategies along a 10-40-year chronosequence on the hilly and gullied Loess Plateau, China, we assessed the effects of R. pseudoacacia afforestation on plant community structure from a functional perspective. We found significant differences among restoration strategies in all the functional composition indices but only functional divergence (FDiv) indices, suggesting that the afforestation practice had a great impact on functional composition but not on functional diversity. Specifically, the plantations had relatively high community-weighted means (CWMs) of specific leaf area (SLA), plant height (PH), seed production, seed mass, root mean diameter, clonality and resprouting capacity and high FDivs of the leaf-height-seed scheme and persistence traits, partially suggesting that the exotic tree could naturalize and coexist with native plants in the study area. Moreover, the relatively high CWMs of woodiness, PH and SLA and high FDiv of erosion-control-related traits found in the plantations indicate that the plantations might have superiority in soil erosion control. R. pseudoacacia also had a homogenization effect on understory functional composition and divergence. Furthermore, we proposed a trait-based effect-and-response framework to find the balance, thus achieving sustainable coexistence of the exotic species with ecosystems. This study may provide new prospects for management practices of R. pseudoacacia plantations and a robust scaffold to maintain safe, resilient and functioning ecosystems.

Celastrol ameliorates autoimmune disorders in Trex1-deficient mice.

Celastrol is one of most potent bioactive molecule isolated from the medicinal plant Tripterygium wilfordii (Thunder God Vine) and is well known for its potential therapeutic value against various chronic diseases including the autoimmune diseases, such as systemic lupus erythematosus and Aicardi-Goutieres syndrome, or other interferonopathies. However, the underlying mechanism of celastrol function remains unclear. Here we showed that celastrol caused inhibition of interferon regulatory factor 3 (IRF3) activation leading to the down-regulation of the interferon response triggered by cytosolic nucleic acids in vitro and in vivo. Moreover, celastrol treatment markedly ameliorates the autoimmune phenotypes including myocarditis, aberrant interferon response and autoantibody production, as well as the excessive T-cell activation in Trex1-/- autoimmune disease mouse model. Collectively, our results indicate that celastrol inhibits interferon response by targeting IRF3 activation and may be used as an effective treatment for interferon response-dependent autoimmune diseases.

Selenylation of Polysaccharide from the Sweet Potato and Evaluation of Antioxidant, Antitumor, and Antidiabetic Activities.

Interest in sweet potato as a functional food is growing. A polysaccharide (SWP) was isolated from the sweet potato tuber and elucidation of its structure as composed of rhamnose, glucose, and galactose undertaken. To improve its activity, selenylation of this novel polysaccharide (Se-SWP) was undertaken by using microwave synthesis. In vitro evaluation showed that the Se-SWP has excellent antioxidant activity on scavenging free radicals and reducing capacity. In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (>50%) and adjust immune factor levels in the mice (IL-2, TNF-α, and VEGF). The antidiabetic potential of Se-SWP was tested in STZ-induced diabetic rats. The results indicated that the Se-SWP treatment significantly reduced the levels of malondialdehyde and other disadvantageous factors that were increased by the STZ treatment. Meanwhile, the Se-SWP treatment caused a significant increase in the activities of enzymatic antioxidants and the levels of nonenzymatic antioxidants in the organs of diabetic rats. All of the activity evaluations indicated that the selenylation method could improve the activity of sweet potato polysaccharide and its efficacy as a potential therapeutic, which will be the focus of further study.

[Characteristics of seed rain on abandoned slopes in the hilly-gullied Loess Plateau, Northwest China].

The objective of this study was to analyze the dynamic characteristics of seed rain on abandoned slopes in the hilly-gullied Loess Plateau region and identify the relationship between seed rain and standing vegetation. Three abandoned slopes were chosen as sampling sites in Zhifanggou watershed. Thirty traps were installed at each site to collect seed rain from October 2010 to April 2013. Standing vegetation was surveyed to identify dominant species in August 2011 and 2012, respectively. Thirty-seven species belonging to seventeen families were identified in the seed rain, and the dominant species, i.e., Lespedeza davurica, Astragalus scaberrimus, Setaria viridis, Cleistogenes squarrosa, Stipa bungeana, Bothriochloa ischcemum, Artemisia scoparia, A. gmelinii, and Heteropappus altaicus, took up to 95.8% of the total seed rain. Three species in seed rain were not found in the standing vegetation. The Sorensen similarity index between seed rain and standing vegetation was 0.77. Seed rain densities were 3737 and 6449 seeds · m(-2) in May 2011-April 2012 and May 2012-April 2013, respectively, and alternate bearing existed. During the study period, seed rain from different positions varied from 3853 to 37923 seeds · m(-2) and belonged to 7-15 species. The results indicated the space limitation of seed dispersal. Seed rain densities were in the middle of the pack compared with similar ecosystems in other studies. High temporal and spatial heterogeneity of seed rain was observed because of rainfall, microtopography and so on.