Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone.

Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.

Somatic embryogenesis and plants from zygotic embryos of coconut (Cocos nucifera L.) in vitro.

Complete plants were grown from zygotic embryos cultured on Y3 basal liquid medium supplemented with coconut milk, BA and NAA. Explants from stem, leaf and rachilla of mature coconut trees turned green and swelled on Y3 semi-solid basal media supplemented with 2,4-D, K, NAA, BA and activated charcoal. Callus was initiated in explants from the subapical regions of the stem on Y3 basal medium supplemented with 2,4-D (4.52×10(2)µM). Globular embryo-like structures were obtained when this callus was subcultured to auxinless medium. Root formation was obtained from leaf explants on Y3 basal medium containing citric acid, ascorbic acid and 2,4-D (4.52×10(2) µM). Globular embryo-like structures were also obtained directly from leaf explants on a Y3 basal medium supplemented with 2,4-D (2.26×10(2) µM). Callus isolated from rachilla explants on Y3 basal medium containing 2,4-D(4.52×10(2) µM), formed nodular structures when transferred to medium with 2,4-D (2.3×10(1) µM). These nodules developed roots from the base of the nodular growth whereas from the upper portion shoots were observed on Y3 basal liquid medium.