[Group intervention from a sensorimotor approach to reduce the intensity of chronic pain]. / Intervención grupal desde un enfoque sensoriomotriz para reducir la intensidad del dolor crónico.

OBJECTIVE: To assess the effectiveness, on people with chronic pain, of an intervention (Time In) designed to reduce pain and to improve psychological symptoms. DESIGN: A randomized clinical trial with a control group, taking three measurements over three months. SETTING: Granada, Spain. PARTICIPANTS: A sample of 40 women aged 18 or older with a history (over 6 months) of chronic pain. The recruitment was in the Fibromyalgia Association of Granada, Spain (AGRAFIM). INTERVENTIONS: Time In is a sensorimotor intervention that combines biomechanical physiotherapeutic procedures and psychological strategies. A weekly session of 3h was planned and the total of the program was developed during five weeks. MAIN MEASUREMENTS: Independent variables: sociodemographic information, clinical history and Time In intervention. Dependent variables: Brief Pain Inventory (BPI-S), Short-Form Health Survey (SF-12), Symptom Check List-90-R (SCL-90-R) and Clinical Outcome in Routine Evaluation (CORE-OM). RESULTS: Significant differences were observed between control group and intervention group of most of the scales used in postintervention and follow up measurements. Thus, significantly lower mean scores were obtained in intensity, interference and areas of pain, quality of life, psychological symptoms and behavioural change. Similar results were observed on d Cohen scores. They were 'very important' on intensity of pain (d=-1.01, d=-0.97) and interference of pain (d=-0.85, d=-0.74), with an improvement percentage from 21% to 30%. CONCLUSIONS: Time In intervention reduces pain and improves psychological symptoms in patients with fibromyalgia; this results in a better quality of life.

Group I metabotropic glutamate receptor plasticity after peripheral inflammation alters nociceptive transmission in the dorsal of the spinal cord in adult rats.

Abstract: The dorsal horn of the spinal cord is a crucial site for pain transmission and modulation. Dorsal horn neurons of the spinal cord express group I metabotropic glutamate receptors (group I mGluRs) that exert a complex role in nociceptive transmission. In particular, group I mGluRs promote the activation of L-type calcium channels, voltage-gated channels involved in short- and long-term sensitization to pain. In this study, we analyzed the role of group I mGluRs in spinal nociceptive transmission and the possible cooperation between these receptors and L-type calcium channels in the pathophysiology of pain transmission in the dorsal horn of the spinal cord. We demonstrate that the activation of group I mGluRs induces allodynia and L-type calcium channel-dependent increase in nociceptive field potentials following sciatic nerve stimulation. Surprisingly, in a model of persistent inflammation induced by complete Freund's adjuvant, the activation of group I mGluRs induced an analgesia and a decrease in nociceptive field potentials. Among the group I mGluRs, mGluR1 promotes the activation of L-type calcium channels and increased nociceptive transmission while mGluR5 induces the opposite through the inhibitory network. These results suggest a functional switch exists in pathological conditions that can change the action of group I mGluR agonists into possible analgesic molecules, thereby suggesting new therapeutic perspectives to treat persistent pain in inflammatory settings.

Balneario de San Nicolás de Alhama (Almería). Historia y generalidades / The San Nicolás de Alhama's Spa (Almería). History and generalities

Se hace una reseña de la situación geográfica del Balneario de San Nicolás, de los antecedentes históricos del mismo y situación actual, así como de sus aguas minero‐medicinales, sus propietarios, el primer análisis realizado por un farmacéutico, la dirección médica y los pacientes que le han frecuentado (AU)

An a ccount of the geographical position of Alhama de Almería'Spa is given, including a brief history of it and its situation nowdays. An particularly reference it is made about the minero‐medicinal waters of this Spa, their proprietaries, the pharmacist who made the first chemical analysis, the sanitary direction and the patients frequented it (AU)

Fenobarbital en el síndrome de Crigler-Najjar tipo 1: una opción terapéutica / Phenobarbital in Crigler-Najjar syndrome type 1: A therapeutic option

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El Balneario de Villavieja (Castellón). Historia y generalidades / The Villavieja’s Spa (Castellón). History and generalities

Se hace una reseña de la situación geográfica del Balneario de Villavieja, de los antecedentes históricos del mismo y situación actual. Se hace mención a sus propietarios, al primer análisis químico de las aguas mineromedicinales de este Balneario así como a los médicos directores, a los pacientes que lo han frecuentado y a las referencias a la acción terapéutica de sus aguas (AU)

An account of the geographical position of Villavieja’s Spa is given, including a brief history of it and its situation nowdays. An particularly reference it is made about their propietaries and the first chemical composition of the mineral waters of this spa, the medical direction of the spa and the patients frequented the spa and another ones in relationship the medically effects of the waters and muthbath (AU)