THREE-YEAR OUTCOMES IN A RANDOMIZED SINGLE-BLIND CONTROLLED TRIAL OF INTRAVITREAL RANIBIZUMAB AND ORAL SUPPLEMENTATION WITH DOCOSAHEXAENOIC ACID AND ANTIOXIDANTS FOR DIABETIC MACULAR EDEMA.

PURPOSE: To report 3-year results of a randomized single-blind controlled trial of intravitreal ranibizumab combined with oral docosahexaenoic acid (DHA) supplementation versus ranibizumab alone in patients with diabetic macular edema. METHODS: There were 26 patients (31 eyes) in the DHA group and 29 (38 eyes) in the control group. Ranibizumab (0.5 mg) was administered monthly for the first 4 months followed by a pro re nata (PRN) regimen. In the experimental group, patients received oral DHA supplementation (1,050 mg/day) (Brudyretina 1.5 g). RESULTS: At 36 months, mean decrease of central subfield macular thickness was higher in the DHA-supplementation group than in controls (275 ± 50 µm vs. 310 ± 97 µm) with significant differences at Months 25, 30, 33, and 34. Between-group differences in best-corrected visual acuity were not found, but the percentages of ETRDS gains >5 and >10 letters were higher in the DHA-supplementation group. Differences serum HbA1c, plasma total antioxidant capacity values, erythrocyte DHA content, and serum IL-6 levels were all significant in favor of the DHA-supplementation group. CONCLUSION: The addition of a high-rich DHA dietary supplement to intravitreal ranibizumab was effective to achieve better sustained improvement of central subfield macular thickness outcomes after 3 years of follow-up as compared with intravitreal ranibizumab alone.

COMBINED INTRAVITREAL RANIBIZUMAB AND ORAL SUPPLEMENTATION WITH DOCOSAHEXAENOIC ACID AND ANTIOXIDANTS FOR DIABETIC MACULAR EDEMA: Two-Year Randomized Single-Blind Controlled Trial Results.

PURPOSE: To assess the 2-year effectiveness of intravitreal ranibizumab combined with a dietary supplement rich in docosahexaenoic acid (DHA) plus antioxidants in 62 patients with diabetic macular edema. METHODS: In a randomized single-blind controlled study, 33 subjects (42 eyes) received intravitreal ranibizumab alone and 29 (34 eyes) combined with DHA (1,050 mg/day). Monthly ranibizumab (0.5 mg) was given for the first 4 months followed by on as-needed treatment. RESULTS: At 24 months, the difference between groups in the decrease of central subfield macular thickness was significant in favor of the DHA supplementation group (95% confidence interval of the difference 7.20-97.656; P = 0.024), although improvement in best-corrected visual acuity measured in the Early Treatment Diabetic Retinopathy Study letters did not reach statistical significance (95% confidence interval 5.4-11.2, P < 0.66). At 24 months, gains of >5 and >10 letters were significantly higher in the DHA supplementation group as compared with controls when the worse and better seeing eyes were considered but other differences at 12 months and 24 months were not found. CONCLUSION: Intravitreal ranibizumab combined with DHA supplementation reduced central subfield macular thickness after 2 years of follow-up as compared with ranibizumab alone in patients with diabetic macular edema. This anatomical improvement was accompanied by a trend for an amelioration of vision.

Valoración multimétodo de la composición corporal en karatecas / Multimethod valuation of the body composition in karatecas

La imporatncia que la constitución física, tanto la composición corporal como el somatotipo, presenta con relación al rendimiento deportivo ha sido ampliamente estudiada en múltiples disciplinas atléticas dado que existen patrones de referencia construidos a partir de los individuos que configuran la élite de cada deporte. En el caso del kárate, la escasez de trabajos con deportistas de nuestro país nos animó a realizar un estudio de un grupo de karatecas utilizando técnicas de Cineantropometría Bioimpedanciometría y Densiometría Pletismográfica. Hemos estudiado un amplio grupo de karatecas de sexo masculino, de edades comprendidas entre los 20 y los 30 años, con un nivel mínimo de cinturón verde, que entrena un mínimo de 4 horas semanales y que participa en competiciones regionales, nacionales y/o internacionales. Nuestro interés se centró en calcular su Prototipo Morfológico y su Composición Corporal, así como en estudiar el grado de similitud existente entre los diversos métodos que evalúan dicha composición corporal. Nuestro grupo tiene un somatotipo medio (3.4-5.7-1.6), que puede ser definido como Endo-Mesomórfico. Además, no encontramos la suficiente homogeneidad biotipológica en nuestra muestra ya que el Indice de Dispersión del Somatotipo es de 3.05. En cuanto a la composición corporal, el porcentaje de grasa calculado por los diferentes métodos, superó claramente el 10% y el Indice de Masa Corporal (IMC) se situó en 25.1. Por último, observamos unos resultados muy similares en los distintos parámetros hallados mediante Impedanciometría y Densiometría, y más dispares si comparamos cualquiera de estos métodos con los antropométricos clásicos, especialmente en lo referente al compartimento graso y al método de Carter

The importance that the physical constitution, both the corporal composition and somatotype, it presents with relation to the sport performance has been widely studied in multiple athletic disciplines provided that there exit patterns of reference constructed from the individuals who form the elite of each sport. In case of karate, the shortage of works with sportsmen of our country animated to us to realize a study of a group of karatecas using technologies of Kinanthropometry, Bioelectrical-Impedance and Plethysmographic Densitometry. We have studied a wide group of karatecas of masculine sex, of ages includes between 20 and 30 years, with a minimal level of green belt, which they dedicate to the training at least 4 weekly hours and which they take part in competitions regionals, nationals and /or internationals. Our interest centred on calculating its Morphologic Protoype and its Corporal Composition, as well as on studing the degree of existing similarity between the diverse methods that evaluate the above mentioned corporal composition. Our group proved an average somatotype had (3.4-5.7-1.6), which it can be defined as Endo-Mesomorfic. In addition, we did not find sufficient biotipologycal homogeneity in our sample since the Somatotype Dispersion Index was of 3.05. As for the corporal composition, the percentage of fat calculated by the different methods, overcame clearly 10% and the Body Mass Index (BMI) placed in 25.1. Finally, we observed very similar results in the different parameters found by means of Impedance and Densiometry, and more unlike if we compared anyone of these method with the classic anthropometrics, specially in what concerns to the greasy compartment and the method of Carter