1.
J Org Chem
; 68(5): 1659-64, 2003 Mar 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12608776
RESUMO
The biosynthetic origins of the diarrhetic shellfish poisoning toxins DTX-5a and DTX-5b have been elucidated by supplementing cultures of the producing organism Prorocentrum maculosum with stable isotope labeled precursors and determining the incorporation patterns by 13C NMR spectroscopy. The amino acid residue in the sulfated side chain is found to originate from glycine, and oxygen insertion in the chain is shown to occur after polyketide formation.