RESUMO
PURPOSE: Antiangiogenic therapy is crucial for advanced hepatocellular carcinoma (HCC) treatment. Interleukin (IL)-6 is an inflammatory response mediator that can promote angiogenesis. We explored its prognostic role in patients with advanced HCC. METHODS: We had two patient cohorts, both comprising patients who received sorafenib-containing therapy as the first-line treatment for advanced HCC. We explored the best cut point for pretreatment plasma IL-6 levels in the exploration cohort and then confirmed it in the validation cohort. RESULTS: In total, 55 and 73 patients constituted the exploration and validation cohorts, respectively. In the exploration cohort, a cut point of 4.28 pg/ml was the best for defining high and low IL-6 levels because it could most effectively differentiate overall survival (OS). On application of this cut point to the validation cohort, patients with high plasma IL-6 levels, compared with patients with low IL-6 levels, exhibited significantly poorer OS (median, 8.0 vs 13.9 months, P = 0.031) but similar progression-free survival or treatment response. After adjusting for patient demographics and tumor characteristics, a high plasma IL-6 level remained an independent predictor of poor OS (hazard ratio 2.594, P = 0.005). CONCLUSION: High pretreatment plasma IL-6 levels were associated with poor prognosis of patients with advanced HCC.
Assuntos
Carcinoma Hepatocelular/sangue , Interleucina-6/sangue , Neoplasias Hepáticas/sangue , Niacinamida/análogos & derivados , Compostos de Fenilureia/uso terapêutico , Inibidores de Proteínas Quinases/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/tratamento farmacológico , Carcinoma Hepatocelular/genética , Estudos de Coortes , Intervalo Livre de Doença , Humanos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/genética , Pessoa de Meia-Idade , Niacinamida/administração & dosagem , Niacinamida/uso terapêutico , Compostos de Fenilureia/administração & dosagem , Prognóstico , Inibidores de Proteínas Quinases/administração & dosagem , Sorafenibe , Adulto JovemRESUMO
Due to the influence of endocrine, menopausal women are easily affected by osteoporosis. Nowadays, with the popularity of preventive medicine, the proportion of the public willing to accept alternative therapies has increased. In this study alternative therapies, including Chinese medicine, diet, exercise, aromatherapy, acupressure and acupuncture were integrated, to prevent osteoporosis in menopausal women. It is expected that this study will enhance the quality of nursing and expand the prospects of nursing care in this field.