RESUMO
OBJECTIVE: To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain. STUDY DESIGN: Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain. RESULTS: In total, 398 patients with a mean age of 34.6⯱â¯7.2 years were treated with a combination of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7% of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months of treatment, this percentage decreased to 87.2% (pâ¯=â¯0.074) and at 6 months the percentage was 82.7% (pâ¯<â¯0.05). CONCLUSIONS: Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.
Assuntos
Acetilcisteína/uso terapêutico , Antioxidantes/uso terapêutico , Bromelaínas/uso terapêutico , Endometriose/complicações , Dor Pélvica/tratamento farmacológico , Ácido Tióctico/uso terapêutico , Adulto , Combinação de Medicamentos , Feminino , Humanos , Dor Pélvica/etiologia , GravidezRESUMO
Objetivos: realizar una revisión sobre la eficacia y seguridad de los tratamientos homeopáticos durante la gestación Métodos: revisión de la literatura. Resultados: los productos homeopáticos más utilizados durante la gestación, en el trabajo del parto y durante el puerperio, son: Caulophyllum, Actaea racemosa, Árnica montana y China rubra. Existen pocos estudios comparativos que hayan analizado la eficacia de estos productos frente a placebo o frente a tratamientos médicos tradicionales. Una revisión Cochrane no encontró evidencias para recomendar el uso de homeopatía en el trabajo de parto. Además, los tratamientos homeopáticos no están exentos de posibles efectos secundarios. Conclusiones: no existe evidencia científica de calidad para apoyar el uso de tratamientos homeopáticos durante la gestación y el trabajo de parto (AU)
Objectives: To assess the efficacy and safety of homoeopathy during pregnancy through a literature review. Methods: Literature review. Results: The homoeopathic treatments most commonly used during pregnancy, labour and the postpartum period are Caulophyllum, Actaea racemosa, Árnica montana and China rubra. Few studies have compared homoeopathy with either placebo or traditional treatments. A Cochrane review found no evidence to recommend the use of homoeopathy during labour. Moreover, homoeopathic treatments are not free from possible side effects. Conclusion: There is insufficient good quality evidence to support the use of homoeopathy during pregnancy and labour (AU)
Assuntos
Humanos , Feminino , Homeopatia , Gravidez/fisiologia , Medicamento Homeopático , Qualidade dos Medicamentos Homeopáticos , Trabalho de Parto/fisiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Resultado do Tratamento , Caulophyllum , Cimicifuga/uso terapêutico , 26049/uso terapêuticoRESUMO
Presentamos el caso de una mujer de 28 años, con 2 abortos tardíos previos causados por anticuerpos anti-M. En la actual gestación es tratada desde la semana 23 hasta la semana 34 con inmunoglobulinas intravenosas fetales, con resultado satisfactorio. Aunque no hay estudios randomizados y controlados que indiquen que las inmunoglobulinas fetales son efectivas en el manejo de la isoinmunización, pequeñas series de casos sugieren resultados prometedores (AU)
We present the case of a 28-year-old woman with two prior late miscarriages caused by anti-M antibodies, leading to alloimmunization of her previous pregnancies. During this pregnancy, she was successfully treated with intravenous immunoglobulins administered from the 23th to the 34th week of pregnancy. There are no randomized trials to indicate whether the antenatal use of intravenous immunoglobulin is effective in the management of fetal red blood cell alloimmunization. Several case series suggest a beneficial role in preventing severe fetal anemia (AU)
Assuntos
Adulto , Feminino , Humanos , Gravidez , Eritroblastose Fetal/induzido quimicamente , Eritroblastose Fetal/tratamento farmacológico , Imunoglobulinas Intravenosas/uso terapêutico , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/terapia , Eritroblastose Fetal/diagnóstico , Eritroblastose Fetal/terapia , Fototerapia/métodos , Fototerapia , Isoimunização Rh/diagnóstico , Isoimunização Rh/terapia , Oxigenoterapia/instrumentação , Oxigenoterapia/métodos , Oxigenoterapia , Teste de Coombs/instrumentaçãoRESUMO
Objetivo. Conocer los hábitos de las mujeres españolas en edad fértil, respecto al uso de suplementos vitamínicos y ácido fólico antes y durante el embarazo. Material y método. Encuesta telefónica realizada a una muestra representativa de 1.020 mujeres residentes en España de 15 a 49 años de edad, durante el mes de marzo del 2013. Resultados. Una de cada 4 mujeres españolas planifica su embarazo. Como consecuencia de esta falta de planificación, solo el 28,6% de las mujeres había tomado un suplemento de ácido fólico con anterioridad al momento de quedar embarazada. Conclusiones. Sigue existiendo la necesidad de informar y aconsejar a las mujeres en edad fértil sobre la conveniencia de utilizar ácido fólico previamente a un embarazo. Parecen necesarias campañas institucionales que promuevan tanto la planificación de un futuro embarazo, como el uso de suplementos vitamínicos antes y durante el mismo (AU)
Objective. To identify the use of folic acid and other vitamins in Spanish women of fertile age before and during pregnancy. Material and method. A representative survey of 1020 Spanish women aged 15 to 49 years was carried out in March 2013. Results. Only one quarter of Spanish women planned their pregnancies and,as a result, only 28.6% of women took folic acid before becoming pregnant. Conclusions. There is a lack of information about the role and importance of folic acid to prevent neural tube defects. Institutional campaigns are needed to promote both pregnancy planningand the use of vitamin supplements before and during pregnancy (AU)