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Chin J Integr Med ; 28(11): 1048-1056, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32876860

RESUMO

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.


Assuntos
Doença de Alzheimer , Microbioma Gastrointestinal , Doenças Neurodegenerativas , Humanos , Doença de Alzheimer/tratamento farmacológico , Sistema Hipotálamo-Hipofisário , Medicina Tradicional Chinesa , Sistema Hipófise-Suprarrenal , Encéfalo/patologia
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