RESUMO
Phytochemical investigation on the roots of Swietenia macrophylla yielded one new pharagmalin-type limonoid named 2-dehydroxyl-swietephragmin C (1) and one new xanthone, 1,5-dihydroxy-6-methoxy-6',6'-dimethyl-2H-pyrano[2',3':3,2]xanthone (2), in addition to three known compounds. The structures of the new compounds were unambiguously determined by comprehensive spectroscopic methods (NMR, UV, IR, MS), as well as by comparison with the reported data in the literature. Xanthones were reported from Swietenia genus for the first time.
Assuntos
Limoninas/isolamento & purificação , Limoninas/farmacologia , Meliaceae/química , Raízes de Plantas/química , Xantonas/isolamento & purificação , Xantonas/farmacologia , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/farmacologia , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Bactérias/efeitos dos fármacos , Linhagem Celular Tumoral , Inibidores da Colinesterase/farmacologia , Fungos/efeitos dos fármacos , Inibidores de Glicosídeo Hidrolases/química , Inibidores de Glicosídeo Hidrolases/farmacologia , Humanos , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Espectrometria de Massas por Ionização por ElectrosprayRESUMO
One new monoterpenoid, nerol oxide-8-carboxylic acid (1), and one new flavonoid glycoside, claulansoside A (2), together with six known compounds, clausenamide (3), quercetin (4), isorhamnetin (5), dihydromyric (6), 2",3"-dihydroxyanisolactone (7) and (E,E)-8-(7-hydroxy-3,7-dimethylocta-2,5-dienyloxy)psoralen (8), have been isolated from the peels of Clausena lansium (Lour.) Skeels. Their structures were determined using a combination of 1D, and 2D NMR (HMQC, HMBC, COSY and NOESY) techniques, and HR-ESI-MS analyses. Compounds 1 and 7 exhibited antibacterial activity against Staphylococcus aureus with the diameter of inhibition zones of 11.5 mm and 14.2 mm. Compounds 3 and 6 showed α-glucosidase inhibitory activity in vitro.
Assuntos
Clausena/química , Flavonoides/isolamento & purificação , Monoterpenos/isolamento & purificação , Monoterpenos Acíclicos , Flavonoides/química , Frutas/química , Testes de Sensibilidade Microbiana , Estrutura Molecular , Monoterpenos/químicaRESUMO
A phytochemical investigation on the peels of Clausena lansium (Lour.) Skeels led to the isolation of two new monoterpenoid coumarins, named clauslactone V (1) and clauslactone W (2), together with three known analogues (3-5). Their structures were elucidated by spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). All the compounds were evaluated for hypoglycemic activity, and compounds 1-5 showed α-glucosidase inhibitory activity in vitro.
Assuntos
Clausena/química , Cumarínicos/farmacologia , Medicamentos de Ervas Chinesas/farmacologia , Inibidores de Glicosídeo Hidrolases/farmacologia , Hipoglicemiantes/farmacologia , Monoterpenos/farmacologia , Cumarínicos/química , Cumarínicos/isolamento & purificação , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/isolamento & purificação , Frutas/química , Inibidores de Glicosídeo Hidrolases/química , Inibidores de Glicosídeo Hidrolases/isolamento & purificação , Hipoglicemiantes/química , Hipoglicemiantes/isolamento & purificação , Estrutura Molecular , Monoterpenos/química , Monoterpenos/isolamento & purificação , Plantas Medicinais , alfa-Glucosidases/efeitos dos fármacosRESUMO
A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro α-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.
Assuntos
Alcaloides/isolamento & purificação , Carbazóis/isolamento & purificação , Clausena/química , Medicamentos de Ervas Chinesas/isolamento & purificação , Inibidores de Glicosídeo Hidrolases/isolamento & purificação , Staphylococcus aureus/efeitos dos fármacos , Alcaloides/química , Alcaloides/farmacologia , Antibacterianos/farmacologia , Carbazóis/química , Carbazóis/farmacologia , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Inibidores de Glicosídeo Hidrolases/química , Inibidores de Glicosídeo Hidrolases/farmacologia , Concentração Inibidora 50 , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Caules de Planta/químicaRESUMO
To resolve the key environmental problems in coal mine areas of environmental phytoremediation, symbiosis of arbuscular mycorrhizal fungi (AMF) and Amorpha fruticosa was investigated. Effects of AMF on the root growth of Amorpha fruticosa and degenerated soil in coal mining subsidence area were studied. Results showed that after 5 months inoculation, AMF improved the shoot and root growth of Amorpha fruticosa. After inoculation with arbuscular mycorrhiza (AM) for 5 months, the inoculation significantly increased root colonization of Amorpha fruticosa. Total glomalin and easily extractable glomalin were increased significantly in the incubated soil. The content of phosphorus and organic matter were increased in the rhizosphere soil. Population of microorganism increased obviously. All the above results show that their ecological effects are significantly improved. AM would promote rhizosphere soil that will help the sustainability of ecological systems in mining area. It is really of great significance to keep the ecological system stability.