RESUMO
Four new pavine alkaloids, (+)-eschscholtzidine-N-oxide (1), (-)-12-hydroxycrychine (2), (-)-12-hydroxy-O-methylcaryachine (3), and (-)-N-demethylcrychine (4), and four new proaporphine alkaloids, isocryprochine (5), prooxocryptochine (6), isoamuronine (7), and (+)-8,9-dihydrostepharine (8), together with nine known compounds were isolated from an ethanol extract of the wood of Cryptocarya chinensis. Their structures were elucidated by spectral analysis (NMR and MS), and the structures of 2 and 5 were confirmed by X-ray crystallography.
Assuntos
Alcaloides/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Lauraceae/química , Alcaloides/química , Cristalografia por Raios X , Medicamentos de Ervas Chinesas/química , Espectrometria de Massas , Medicina Tradicional Chinesa , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Plantas Medicinais/química , Espectroscopia de Infravermelho com Transformada de Fourier , Taiwan , MadeiraRESUMO
Two new tetranortriterpenoids, 7-isovaleroylcycloseverinolide (1) and 7-isovaleroylcycloepiatalantin (2), together with 28 known compounds, were isolated and characterized from the root bark of Severinia buxifolia collected in Hainan. The structures of 1 and 2 were elucidated on the basis of spectral evidence including 2D NMR and X-ray techniques. The cytotoxicity of several acridone alkaloid isolates (3-8) was evaluated against a small tumor cell panel.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Plantas Medicinais/química , Triterpenos/isolamento & purificação , Acridinas/química , Acridinas/farmacologia , Acridonas , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Carcinoma Hepatocelular , Neoplasias do Colo , Cristalografia por Raios X , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Humanos , Células KB , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Raízes de Plantas/química , Taiwan , Triterpenos/química , Triterpenos/farmacologia , Células Tumorais Cultivadas/efeitos dos fármacos , Células Tumorais Cultivadas/metabolismoRESUMO
Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18. 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells.
Assuntos
Acetileno/análogos & derivados , Fármacos Anti-HIV/isolamento & purificação , Artemisia/química , Plantas Medicinais , Inibidores da Agregação Plaquetária/isolamento & purificação , Acetileno/farmacologia , Animais , Plaquetas/efeitos dos fármacos , Ácidos Cafeicos/farmacologia , Cumarínicos/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Inibidores da Agregação Plaquetária/farmacologia , Coelhos , EspectrofotometriaRESUMO
One new biphenyl ether, aristogin C (1), and two new porphyrins, aristophylls A (2) and B (3), as well as 11 known compounds, were isolated from the leaves of Aristolochia elegans. Their structures were elucidated according to the spectroscopic (NMR and MS) analyses or by comparison with literature values.