RESUMO
Fat emulsion is a drug commonly used clinically for parenteral nutrition support in critically ill patients.With the development of the pharmaceutical industry, fat emulsion has formed a variety of different formulations, among which different types of fat emulsion have their own metabolic and body energy supply characteristics, and the application indications are also different. In addition to providing the supply of nutrients, the role of fat emulsion in anti-toxicity, immune regulation, anti-inflammatory, anti-shock, cardiopulmonary resuscitation and other aspects has gradually been discovered. This article reviews the existing evidence-based medical evidence and expounds the mechanism and therapeutic role of fat emulsion in the treatment of critically ill patients with poisoning. Its value in the treatment of critically ill patients with poisoning was discussed, and some references were provided for the application of non-nutritional functions of fat emulsion in the future.
Assuntos
Estado Terminal , Emulsões Gordurosas Intravenosas , Humanos , Emulsões Gordurosas Intravenosas/uso terapêutico , Emulsões Gordurosas Intravenosas/metabolismo , Estado Terminal/terapia , Nutrição ParenteralRESUMO
This review illustrates the distribution of tropane alkaloids within the families Solanaceae, Erythroxylaceae, Proteaceae, Euphorbiaceae, Rhizophoraceae, Convolvulaceae and Cruciferae. Whereas tropane alkaloids are characteristic of the genera Datura, Brugmansia (tree datura) and Duboisia of the Solanaceae, the distribution is more widespread with novel tropane derivatives in families not traditionally associated with these bases. The chemical nature of more recently discovered water-soluble calystegines and the di- and trimeric forms from the Convolvulaceae (e.g. schizanthines from Schizanthus spp.), truxillines from Bolivian coca leaves and moonines of Erythroxylum moonii are highlighted. Where possible and appropriate, links between the phytochemistry and taxonomy are discussed.
Assuntos
Magnoliopsida/química , Plantas Medicinais/química , Tropanos/química , Brassicaceae/química , Geografia , Rosales/química , Solanaceae/químicaRESUMO
New ways for medicinal plant improvement and for the production of plant drugs have opened up as the result of advances in plant biotechnology and increasing interest in plant-derived pharmaceuticals. This article highlights plant improvement of Duboisia and production of tropane alkaloids using modern techniques such as plant tissue and cell culture, root culture, radioimmunoassay in tropane alkaloid analysis, and molecular biology in the studies of tropane biosynthesis.
Assuntos
Biotecnologia , Plantas Medicinais/metabolismo , Tropanos/metabolismo , Austrália , Células Cultivadas , Técnicas de Cultura , Ornitina/metabolismo , Fenilalanina/metabolismo , Plantas Medicinais/citologia , Plantas Medicinais/crescimento & desenvolvimento , Radioimunoensaio , Escopolamina/metabolismoRESUMO
The Lys fragment of mung bean trypsin inhibitor can combine with bovine trypsin to form a complex at an equal molar ratio. The single crystals of the complex were obtained by using the micro-still-setting method and the X-ray diffraction extended to 1.8A resolution. Its space group is P212121 with cell dimensions a = 62.9(1)A, b = 63.4(1)A and c = 69.7 (2)A. There is one complex molecule in a crystallographic asymmetric unit.